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This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.
This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.
Videos via app: simply download the SN More Media app free of charge, scan a link with the play button or use the printed QR code and immediately play the video on your smartphone or tablet.
This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.
This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.
Videos via app: simply download the SN More Media app free of charge, scan a link with the play button or use the printed QR code and immediately play the video on your smartphone or tablet.
Gerhard Klebe is Professor of Pharmaceutical Chemistry at Philipps-Universität Marburg. He retired in April 2020. His research focuses on structure-activity relationships, 3D-QSAR methods, conformational and pharmacophore analyses, docking methods, database analyses, protein crystallography, structure-based drug design and the biophysical characterisation of protein-ligand interactions. Before his appointment in Marburg, he taught at the University of Heidelberg and worked in the main laboratory of BASF AG in Ludwigshafen in the field of drug design and crystallography.
| Erscheinungsjahr: | 2025 |
|---|---|
| Fachbereich: | Toxikologie |
| Genre: | Mathematik, Medizin, Naturwissenschaften, Technik |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Inhalt: |
xxviii
686 S. 441 farbige Illustr. 686 p. 441 illus. in color. With online files/update. |
| ISBN-13: | 9783662689974 |
| ISBN-10: | 3662689979 |
| Sprache: | Englisch |
| Einband: | Gebunden |
| Autor: | Klebe, Gerhard |
| Hersteller: |
Springer-Verlag GmbH
Springer Berlin Heidelberg |
| Verantwortliche Person für die EU: | Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com |
| Maße: | 285 x 215 x 42 mm |
| Von/Mit: | Gerhard Klebe |
| Erscheinungsdatum: | 05.02.2025 |
| Gewicht: | 2,176 kg |
Gerhard Klebe is Professor of Pharmaceutical Chemistry at Philipps-Universität Marburg. He retired in April 2020. His research focuses on structure-activity relationships, 3D-QSAR methods, conformational and pharmacophore analyses, docking methods, database analyses, protein crystallography, structure-based drug design and the biophysical characterisation of protein-ligand interactions. Before his appointment in Marburg, he taught at the University of Heidelberg and worked in the main laboratory of BASF AG in Ludwigshafen in the field of drug design and crystallography.
| Erscheinungsjahr: | 2025 |
|---|---|
| Fachbereich: | Toxikologie |
| Genre: | Mathematik, Medizin, Naturwissenschaften, Technik |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Inhalt: |
xxviii
686 S. 441 farbige Illustr. 686 p. 441 illus. in color. With online files/update. |
| ISBN-13: | 9783662689974 |
| ISBN-10: | 3662689979 |
| Sprache: | Englisch |
| Einband: | Gebunden |
| Autor: | Klebe, Gerhard |
| Hersteller: |
Springer-Verlag GmbH
Springer Berlin Heidelberg |
| Verantwortliche Person für die EU: | Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com |
| Maße: | 285 x 215 x 42 mm |
| Von/Mit: | Gerhard Klebe |
| Erscheinungsdatum: | 05.02.2025 |
| Gewicht: | 2,176 kg |
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