Perioperative Inflammation as Triggering O...

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Beschreibung

The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.
With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.

Über den Autor

Michael Retsky, PhD, is Research Associate, Harvard TH Chan School of Public Health and Honorary Faculty, University College London

Romano Demicheli, MD, PhD, is Senior Researcher, Istituto Nazionale Tumori di Milano

Zusammenfassung

Will thoroughly explain previously unconnected clinical date such as why mammography works better for women age 50-59 than for women age 40-49;

Will explore why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes and may also explain the racial disparity in outcome;

Focuses on post-operative inflammation and its role in metastatic relapse.

Includes supplementary material: [...]

Inhaltsverzeichnis

The Natural History of Breast Cancer.- Perioperative Inflammation as Triggering Origin of Metastasis Development.- Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients.- Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation.- Circulating tumor cells as predictive marker in metastatic disease.- Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints.- Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs.- The impact of wound inflammation on cancer progression; Studies in fish and patients.- Long term consequences of acute inflammation in cancer surgery: New findings and perspectives.- Cancer: Nurture and Nature.- The systemic effects of local treatments (surgery and radiotherapy) of breast cancer.

Details

Erscheinungsjahr:	2017
Fachbereich:	Therapie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	xxiii 236 S. 10 s/w Illustr. 39 farbige Illustr. 236 p. 49 illus. 39 illus. in color.
ISBN-13:	9783319579429
ISBN-10:	3319579428
Sprache:	Englisch
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Demicheli, Romano Retsky, Michael W.
Herausgeber:	Michael W Retsky/Romano Demicheli
Auflage:	1st ed. 2017
Hersteller:	Springer Nature Switzerland Springer International Publishing Springer International Publishing AG
Maße:	241 x 160 x 20 mm
Von/Mit:	Romano Demicheli (u. a.)
Erscheinungsdatum:	07.07.2017
Gewicht:	0,559 kg

Artikel-ID: 109460825