Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts

G-Quadruplex DNA and RNA.- CD Study of the G-Quadruplex Conformation.- Revealing the Energetics of Ligand-Quadruplex Interactions using Isothermal Titration Calorimetry.- Biosensor-Surface Plasmon Resonance: Label Free Method for Investigation of Small Molecule-Quadruplex Nucleic Acid Interactions.- Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation.- Mass Spectroscopic Study of G-Quadruplex.- G-Quadruplex Stability from DSC Measurements.- X-Ray Crystallographic Studies of G-Quadruplex Structures.- NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.- Using Molecular Dynamics Free Energy Simulation to Compute Binding Affinities of DNA G-Quadruplex Ligands.- Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes.- A DNA Polymerase Stop Assay for Characterization of G-Quadruplex Formation and Identification of G-Quadruplex-Interactive Compounds.- Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region.- Characterization of Co-Transcriptional Formation of G-Quadruplexes in Double-Stranded DNA.- Quantitative Analysis of Stall of Replicating DNA Polymerase by G-Quadruplex Formation.- Single-Molecule Investigations of G-Quadruplex.- Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-motif Sequences in the DNA Origami Frame using High-Speed AFM.- G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy.- High-Throughput Screening of G-Quadruplex Ligands by FRET Assay.- Targeting G-Quadruplexes with PNA Oligomers.- Primer-Modified G-Quadruplex-Au Nanoparticles for Colorimetric Assay of Human Telomerase Activity and Initial Screening of Telomerase Inhibitors.- Heme¿G-Quadruplex DNAzymes: Conditions for Maximizing their Peroxidase Activity.- In Vivo Chemical Probing for G-Quadruplex Formation.- G-Quadruplex Visualization In Cells via Antibody and Fluorescence Probe.- In Cell NMR Spectroscopy: Investigation of G-Quadruplex Structures inside Living Xenopus laevis Oocytes.- 19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures using 19F-labeled Nucleobase.