Written by leading experts in the field botulinum neurotoxins

Provides the current status of basic botulinum neurotoxin research

Provides in depth articles on neurotoxins for further medical applications by means of recombinant technologies

Includes supplementary material: [...]

Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes.- Assembly and Function of the Botulinum Neurotoxin Progenitor Complex.- Uptake of Botulinum Neurotoxin in the Intestine.- Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity.- The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go?.- Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons.- Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission.- Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins.- Persistence of Botulinum Neurotoxin Inactivation of Nerve Function.- Structure-Based Drug Discovery for Botulinum Neurotoxins.- Complexity of Botulinum Neurotoxins: Challenges for Detection Technology.- Progress in Cell Based Assays for Botulinum Neurotoxin Detection.- Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics.- Botulinum Toxin: Application, Safety, and Limitations.