About the Editors

Timothy C. Wang, MD, Chief, Division of Digestive and Liver Diseases; Silberberg Professor of Medicine, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY, USA.

Michael Camilleri, MD, Atherton and Winifred W. Bean Professor of Medicine, Pharmacology and Physiology, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Associate Editors

Benjamin Lebwohl, MD, Associate Professor of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA.

Anna Lok, MD, Alice Lohrman Andrews Research Professor of Hepatology, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.

William J. Sandborn, MD, Professor of Medicine, University of California San Diego, CA, USA.

Kenneth K. Wang, MD, Russell G. and Kathleen M. Van Cleve Professor of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Gary D. Wu, MD, Ferdinand G. Weisbrod Professor of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Contributors, ix

Preface, xvii

About the companion website, xviii

PART 1 Anatomy and development

1 Esophagus: anatomy and structural anomalies, 3
Ikuo Hirano

2 Stomach and duodenum: anatomy and structural anomalies, 15
Erik C. von Rosenvinge and Jean-Pierre Raufman

3 Small intestine: anatomy and structural anomalies, 22
Deborah C. Rubin and Jacob C. Langer

4 Colon: anatomy and structural anomalies, 27
Bo Shen

5 Pancreas: anatomy and structural anomalies, 34
Kazuki N. Sugahara and John A. Chabot

6 Abdominal cavity: anatomy, structural anomalies, and hernias, 40
Stella Joyce, Kevin P. Murphy, Michael M. Maher, and Owen J. O'Connor

7 Gallbladder and biliary tract: anatomy and structural anomalies, 50
Theodore H. Welling

8 Liver: anatomy, microscopic structure, and cell types, 59
Maria Westerhoff and Laura Lamps

PART 2 Gastrointestinal diseases

A Esophagus

9 Motility disorders of the esophagus, 71
Joan W. Chen, John E. Pandolfino, and Peter J. Kahrilas

10 Gastroesophageal reflux disease, 83
Dustin A. Carlson, John E. Pandolfino, and Peter J. Kahrilas

11 Eosinophilic esophagitis, 97
Yael Haberman Ziv, Margaret H. Collins, Nirmala Gonsalves, David A. Katzka, and Marc E. Rothenberg

12 Esophageal infections and disorders associated with acquired immunodeficiency syndrome, 100
C. Mel Wilcox

13 Esophageal neoplasms, 108
Adam J. Bass and Anil K. Rustgi

14 Miscellaneous diseases of the esophagus, 118
Craig C. Reed, Evan S. Dellon, and Nicholas J. Shaheen

B Stomach

15 Disorders of gastric emptying, 131
Henry P. Parkman MD

16 Peptic ulcer disease, 141
Jonathan R. White, Krish Ragunath, and John C. Atherton

17 Zollinger-Ellison syndrome, 153
Robert T. Jensen and David C. Metz

18 Gastritis and gastropathy, 159
M. Blanca Piazuelo, Richard M. Peek, Jr, and M. Kay Washington

19 Tumors of the stomach, 170
Philip I. Craig and Emad M. El-Omar

20 Miscellaneous diseases of the stomach, 177
Tamas A. Gonda and Abraham Krikhely

C Small intestine

21 Dysmotility of the small intestine and colon, 182
David O. Prichard and Lawrence Szarka

22 Disorders of epithelial transport, metabolism, and digestion in the small intestine, 190
Richard J. Grand

23 Celiac disease, 196
Daniel A. Leffler and Benjamin Lebwohl

24 Short bowel syndrome and small bowel transplantation, 204
John K. DiBaise, Samuel Kesseli, and Debra Sudan

25 Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections, 209
Gail A. Hecht, Jerrold R. Turner, Phillip I. Tarr, and Mitchell B. Cohen

26 Chronic infections of the small intestine, 216
Beth Gordon, Mary Flanagan, and Séamus Hussey

27 Tumors of the small intestine, 225
Barbara H. Jung and Maria Rosario Ferreira

28 Miscellaneous diseases of the small intestine, 231
Marc S. Levin

D Inflammatory bowel disease

29 Ulcerative colitis: clinical manifestations and management, 239
Siddharth Singh

30 Crohn's disease: clinical manifestations and management, 255
Gil Y. Melmed, Christina Ha, and Dermot P.B. McGovern

E Colon

31 Irritable bowel syndrome, 264
Elizabeth J. Videlock and Lin Chang

32 Diverticular disease of the colon, 280
Mona Rezapour and Neil Stollman

33 Anorectal diseases, 287
Adil E. Bharucha and Arnold Wald

34 Polyps of the colon and rectum, 304
Daniel C. Chung and John J. Garber

35 Malignant tumors of the colon, 309
Amin K. Soltani, Jay Luther, and Andrew T. Chan

36 Polyposis syndromes, 317
Marcia Cruz-Correa and Gabriella Torres

37 Colorectal cancer screening, 336
Uri Ladabaum

F Pancreas

38 Acute pancreatitis, 341
Timothy B. Gardner

39 Chronic pancreatitis, 358
Mitchell L. Ramsey, Zarine K. Shah, Darwin L. Conwell, and Phil A. Hart

40 Pancreatitis of genetic and complex etiologies, 365
David C. Whitcomb

41 Cystic lesions of the pancreas, 375
James J. Farrell

42 Neuroendocrine tumors of the pancreas, 383
Yasmin G. Hernandez-Barco and Daniel C. Chung

G Gallbladder and biliary tract

43 Gallstones, 389
Piero Portincasa and David Q.-H. Wang

44 Primary sclerosing cholangitis, 408
Ahmad Hassan Ali and Konstantinos N. Lazaridis

45 Cystic diseases of the liver and biliary tract, 416
James L. Buxbaum and Shelly C. Lu

46 Tumors of the biliary tract, 423
Tushar Patel and Victoria Gomez

H Liver

47 Acute viral hepatitis, 431
Marc G. Ghany and T. Jake Liang

48 Chronic hepatitis B and D, 447
Grace L.H. Wong and Anna S. Lok

49 Chronic hepatitis C, 456
Hugo E. Vargas and Andrew W. Tai

50 Drug-induced liver injury, 462
Robert J. Fontana

51 Autoimmune hepatitis, 471
Richard Taubert and Michael P. Manns

52 Primary biliary cholangitis, 476
Marlyn J. Mayo

53 Acute cholangitis and liver abscess, 483
Roman E. Perri and David S. Raiford

54 Hemochromatosis, 486
Paul C. Adams

55 Metabolic diseases of the liver, 490
Jacob Bilhartz and Frederick K. Askari

56 Alcohol-related liver disease, 496
Juan Pablo Arab, Stephen R. Atkinson, and Ramon Bataller

57 Nonalcoholic fatty liver disease, 499
Mohammad S. Siddiqui and Arun J. Sanyal

58 Hepatic fibrosis and cirrhosis, 506
Don C. Rockey

59 Ascites and its complications, 522
Guadalupe Garcia-Tsao

60 Vascular diseases of the liver, 532
José Ferrusquía-Acosta and Laurie D. DeLeve

61 Liver transplantation, 538
Alyson J. Kaplan, Nicole T. Shen, Alyson N. Fox, and Robert S. Brown, Jr

62 Hepatocellular carcinoma, 544
Jorge A. Marrero and Nicole E. Rich

I Miscellaneous

63 Intraabdominal abscesses and fistulas, 549
Ravi Pokala Kiran

64 Diseases of the peritoneum, retroperitoneum, mesentery, and omentum, 556
Jennifer M. Whittington, Scott D. Stevens, and B. Mark Evers

65 Obesity: treatment and complications, 564
Harmeet Malhi and Andres Acosta

66 Surgical complications of metabolic surgery, 575
Todd A. Kellogg, Joseph N. Badaoui, and Omar M. Ghanem

67 Complications of HIV/AIDS and other secondary immunodeficiency states, 588
Phillip D. Smith, C. Mel Wilcox, and Edward N. Janoff

68 Gastrointestinal manifestations of immunological disorders, 596
Paula O'Leary and Fergus Shanahan

69 Parasitic diseases: protozoa, 602
Daniel P. Beiting and Audrey R. Odom John

70 Parasitic diseases: helminths, 611
Joel V. Weinstock

71 Gastrointestinal manifestations of systemic diseases, 629
Seth Sweetser

72 Skin lesions associated with gastrointestinal and liver diseases and oral manifestations of gastrointestinal diseases, 641
Travis W. Vandergriff

73 Intestinal ischemia and vasculitides, 662
Juan-Ramón Malagelada and Carolina Malagelada

74 Radiation injury in the gastrointestinal tract, 677
Lalitha S. Y. Nanduri, Nicole C. Panarelli, and Chandan Guha

PART 3 Diagnostic and therapeutic modalities in gastroenterology

A Endoscopic

75 Upper gastrointestinal endoscopy, 687
Emmanuel Coronel and Irving Waxman

76 Capsule and small bowel endoscopy, 713
Jonathan A. Leighton and Shabana F. Pasha

77 Colonoscopy and sigmoidoscopy, 718
Douglas K. Rex

78 Endoscopic retrograde cholangiopancreatography, 724
Todd H. Baron and Ryan J. Law

79 Gastrointestinal dilation and stent placement, 728
Shayan Irani and Richard A. Kozarek

80 Management of upper gastrointestinal hemorrhage related to portal hypertension, 750
Patrick S. Kamath and Louis-Michel Wong Kee Song

81 Endoscopic diagnosis and treatment of nonvariceal upper gastrointestinal hemorrhage, 769
Andrew W. Yen and Joseph W. Leung

82 Endoscopic management of esophageal, gastric, and duodenal lesions, 775
Neal Shahidi, Sunil Gupta, and Michael J. Bourke

83 Endoscopic management of colorectal lesions, 782
Neal Shahidi, Sunil Gupta, and Michael J. Bourke

84 Minimally invasive surgery: laparotomy, laparoscopy, and robotic surgery, 788
Aashish Rajesh, Nizamuddin Shaikh, and David R. Farley

B Imaging

85 POEM and G-POEM, 796
Mary Raina Angeli Fujiyoshi, Haruhiro Inoue, Yusuke Fujiyoshi, Yuto Shimamura, Haruo Ikeda, and Manabu Onimaru

86 Plain and contrast radiology, 801
Stephen E. Rubesin and Marc S. Levine

87 Abdominal sonography, 813
Stuart Bentley-Hibbert and Dwight Aberle

88 Endoscopic ultrasonography, 822
Margaret G. Keane, Anne Marie Lennon, and Mouen A. Khashab

89 Computed tomography of the gastrointestinal tract, 835
Eric C. Ehman, Siva P. Raman, Karen M. Horton, Pamela T. Johnson, and Elliot K. Fishman

90 Magnetic resonance imaging, 847
Haresh Naringrekar

91 Positron emission tomography, 870
Garima Suman and Val J. Lowe

92 Nuclear...