Editor:


J. Sebag, MD, FACS, FRCOphth, FARVO


VMR Institute for Vitreous Macula Retina


7677 Center Avenue, suite 400


Huntington Beach, CA 92647

Presents a comprehensive overview of the biochemical composition, molecular organization, morphologic structure, physiology and metabolism of the vitreous body of the eye

Highlights both the advances in vitreo-retinal surgery of today with text and video of surgery, along with the non-surgical approaches of the future, namely pharmacologic vitreolysis

Clinicians can use this text as a basic science reference manual and researchers will obtain a better understanding of the problems that confront clinicians, helping direct their research to the areas relevant to clinical problems that need development

PREFACE;
FOREWORD;
INTRODUCTION;
I. BIOCHEMISTRY;
A. Vitreous Proteins;

B.

Hyaluronan and other Carbohydrates in the Vitreus; C. Hereditary Vitreo-Retinopathies ; D. Vitreous Proteomics and Regression of the Fetal Hyaloid Vasculature; E. Diabetic Vitreopathy ; F. Vitreous Biochemistry & Artificial Vitreous ;
II. ANATOMY, DEVELEOPMENT & AGING ;

A
.
Development and Developmental Disorders of Vitreous; B.

Myopic Vitreopathy ; C. Vitreous Aging & Posterior Vitreous Detachment ; D. Hyalocytes: Essential Vitreous Cells in Vitreo-Retinal Health & Disease

; E. Vitreo-Retinal Interface & Inner Limiting Membrane ; F. To See the Invisible - the Quest of Imaging Vitreous;
III. PATHOLOGY/PATHOBIOLOGY ;
A. Congenital Vascular Vitreo-Retinopathies ; B. Anomalous Posterior Vitreous Detachment & Vitreoschisis ; C. Pathology of Vitreo-Maculopathies ; D. Vitreo-Macular Adhesion/Traction & Macular Holes - Pseudo, Lamellar & Full-Thickness ; E. Vitreo-Papillary Adhesion and Traction; F. Vitreous in the Pathobiology of Macular Pucker ; G. Vitreous in Age-related Macular Degeneration ; H. Peripheral Vitreo-Retinal Pathology; I. Role of Vitreous in the Pathogenesis of Retinal Detachment ; J. Cell Proliferation at the Vitreo-Retinal Interface in Proliferative Vitreo-Retinopathy and Related Disorders ; K. Vitreous in Retino-Vascular Diseases and Diabetic Macular Edema ; L. Proliferative Diabetic Vitreo-Retinopathy;
IV. PHYSIOLOGY & PHARMACOTHERAPY ;
A. Vitreous Physiology ; B. Oxygen in Vitreo-Retinal Physiology and Pathology ; C. Vitreous and Iris Neovascularization ; D. Physiology of Accommodation & Role of Vitreous ; E. Principles and Practice of Intravitreal Application of Drugs ; F. Pharmacotherapy of Proliferative Vitreo-Retinopathy ; G. (SiO, PFCs) ;
V. VITREO-RETINAL SURGERY ;
A.
Posterior Vitreo-Retinal Surgery ;
1. Age-Related Macular Degeneration Surgery ; 2. Vitreo-Maculopathy Surgery ; 3. Chromodissection in Vitreo-Retinal Surgery ; 4. Macular Hole & Macular Pucker Surgery with Special Emphasis on Re-Operations ; 5. Surgery of Diabetic Vitreo-Retinopathy & Diabetic Macular Edema ; 6. Vitreous Surgery of Arterial and Venous Retino-Vascular Diseases ; B.
Peripheral Vitreo-Retinal Surgery ;
1. The History of Vitrectomy Instrumentation ; 2. Modern Vitrectomy Cutters ; 3. The Future of Vitrectomy ; 4. Prophylaxis and Cure of Retinal Detachment ; 5. Management of Proliferative Vitreo-Retinopathy ; 6.

Retinectomy in Recalcitrant Retinal Detachments ; 7. Pneumatic Retinopexy ; 8. Floaters and Vision - Current Concepts and Management Paradigms; 9.

Rare Indications for Vitrectomy: Tumor Excision, Optic Nerve Pits, Malignant Glaucoma;
VI. PHARMACOLOGIC VITREOLYSIS ;
A. Pharmacologic Vitreolysis ; B. The History of Pharmacologic Vitreolysis ; C. Pharmacologic Vitreolysis with Tissue Plasminogen Activator ; D. Pharmacologic Vitreolysis with Plasmin ; 1. Basic Science Experiments 2. Clinical Studies ; E. Pharmacologic Vitreolysis with Ocriplasmin; 1. Basic Science Studies; 2. Clinical Studies ; F. Hyaluronidase as a Vitreous Liquefactant ; G. Pharmacologic Vitreolysis with Dispase (Vitreolysin(TM)) ; H. Chondroitinase as a Vitreous Interfactant - Vitreous Dis-insertion in the Human