Preface.Ligandin and Glutathione S-Transferases; Historical Milestones. Families of Glutathione Transferases.Mammalian Glutathione S-Transferase Genes: Structure and Regulation. Combinatorial Protein Chemistry In Three Dimensions: A Paradigm For The Evolution Of Glutathione Transferases With Novel Activities. Substrates and Reaction Mechanisms of GSTs. Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides. GST Polymorphism: Where To Now? Clinical Applications and Functional Analysis. Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development.Physiological Substrates of Glutathione S-Transferases. Glutathione S-transferases as modulators of signal transduction. Glutathione-conjugate transport and Stress-Response Signaling: Role of RLIP76. Glutathione-S-Transferases and Oxidative Injury of Cardiovascular Tissues. Mitochondrial Glutathione S-Transferase Pool in Health and Disease. Activation of Microsomal Glutathione Transferase 1 in Toxicology. Glutathione S-transferase Isozyme Composition of Human Tissues. Enzymology of glutathione S-transferases: Laboratory Methods.