Professor of Anesthesiology, The University Medical Center Groningen, University of Groningen, The Netherlands

Dr. Absalom is internationally recognized as a leading expert on anaesthetic pharmacology and total intravenous anesthesia. He currently serves as Editor of the British Journal of Anaesthesia and is a former editorial board member of Trends in Anaesthesia and Critical Care. He is currently president of the Society for Intravenous Anesthesia (UK). In the past he has served as a board member of ISAP (International Society for Intravenous Anaesthesia) and as vice-president of the World Society of Intravenous Anaesthesia.

Keira P. Mason, MD is an Associate Professor of Anaesthesia (Radiology) at Harvard Medical School, , Boston Children's Hospital, Boston, MA.

Dr. Mason is a Springer author. We recently published the expanded Second Edition of her critically and globally acclaimed book, Pediatric Sedation Outside of the Operating Room, 2nd ed, Mason, ed., (2015).

During 1998-2014, Dr. Mason was Director of Radiology Anesthesia and Sedation at Boston Children's Hospital, where she developed a sedation and anesthesia program that continues to be nationally and internationally recognized. She is considered a pioneer of innovative and safe sedation protocols which have been adopted worldwide. Dr. Mason is past- Vice President of the World Society of Intravenous Anesthesia (Founding Board Member), and a frequent invited lecturer to national and international conferences, including Society of Interventional Radiology, American Society of Anesthesiologists, Radiological Society of North America, International Dental Congress on Anesthesia, Sedation, and Pain Control, Society of Ambulatory Anesthesia, Asian and Oceanic Society of Regional Anesthesia, Japanese Society for Intravenous Anesthesia, International Association of Pediatric Dentistry, All-African Anaesthesia Congress, Asian Society of Paediatric Anesthesiologists, and many others. She is the Course Director for Pediatric Sedation Outside the Operating Room, a conference she initiated through Harvard Medical School and is an active member of the American Society of Anesthesiologists (ASA) Committees. She has authored many book chapters. As a Principal Investigator of numerous studies, some which required approval of the Food and Drug Administration (FDA), she has numerous publications. Dr. Mason continues to serve on expert panels for the FDA. She is on the Editorial Board of the British Journal of Anaesthesia.

PART 1. INTRODUCTION/BACKGROUND.- 1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia.- 2. The Development and Regulation of Commercial Devices for Target - Controlled Drug Infusion.- 3. The Memory Labyrinth: systems, processes and boundaries.- 4. Consciousness and Anaesthesia.- 5. Mechanisms of Intravenous Anaesthetic Action.- PART 2. PRINCIPLES OF PHARMACOLOGICAL MODELING.- 6. Basic Pharmacology: Kinetics and Dynamics for Dummies.- 7. Pharmacokinetic-Pharmacodynamic Modelling of Anesthetic Drugs.- 8. Principles of Target Controlled Infusions.- 9. Performance of Target-Controlled Infusion Systems.- 10. How to Select a PK/PD Model.- PART 3. PHARMACOLOGY OF THE INTRAVENOUS ANESTHETIC AGENTS.- 11. Propofol PK-PD.- 12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions.- 13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children.- 14. Clinical Effects and Applications of Ketamine.- 15. Neuromuscular Blocking Drugs: Pharmacology, Physiology and Clinical Aspects.- 16. New and Upcoming Drugs: Intravenous Anesthetic Agents.- 17. Drug Interactions in Anesthesia.- PART 4. PRACTICAL CONDUCT OF SEDATION AND ANESTHESIA

18. Pumps Pitfalls and Practicalities.- 19. EEG Monitoring of Depth of Anesthesia.- 20. Monitoring the analgesic component of anesthesia.- 21. Intravenous Drugs for Sedation: Target Controlled, Patient Controlled, and Patient Maintained Delivery.- 22. Pediatric TIVA/TCI: Case Presentations and Discussion.- 23. TCI/TIVA Adult Case Studies.- PART 5. SPECIAL POPULATIONS AND PROCEDURES.- 24. Intravenous Anesthesia in Obese Patients.- 25. Pharmacokinetics and Dynamics on the Pediatric Population.- 26. Clinical Pharmacology of Intravenous Sedation in Children.- 27. Sedation of the Critically Ill Child.- 28. TCI & TIVA for Neurosurgery: Considerations and Techniques.- 29. TCI in Special Patients Groups: The Elderly and Obese.- 30. TIVA for Cardiac Surgery.-31. TIVA/TCI in Veterinary Practice.- PART 6. OUTCOME, EDUCATION, SAFETY, AND THE FUTURE.- 32. Advantages, Disadvantages, and Risks of TIVA/TCI.- 33. Economics of TIVA.- 34. Teaching TCI with Human Patient Simulators.- 35. Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science and Clinical Impact.- 36. Health Care Technology, the Human-Machine Interface, and Patient Safety During Intravenous Anesthesia.- 37. Can IV Sedatives Affect Outcome?.- 38. The Benefit and Future of Pharmacogenetics.- 39. Lessons from drug interaction displays.- 40. The Role of Intravenous Agents in Delirium.- 41. Perioperative Cardioprotective Strategies in Noncardiac Surgery.- 42. Opioid Induced Hyperalgesia after Surgery: Clinical Relevance.- 43. Memory, Awareness and Intravenous Anaesthetics.- 44. Awareness and Dreaming During TIVA.- 45. Apoptosis and Neurocognitive Effects of Intravenous Anesthetics.- Epilogues.