The Biology of mRNA: Structure and Function

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Sprache: Englisch

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Beschreibung

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex.

This book shows how new technologies have led to a better understanding of these processes and their connected diseases.

The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.

This book shows how new technologies have led to a better understanding of these processes and their connected diseases.

Über den Autor

Marlene Oeffinger is Associate Research Professor at the Institut de recherches cliniques de Montréal (IRCM) and the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada, and Adjunct Professor in the Division of Experimental Medicine at McGill University. Her laboratory uses Proteomic, RNomic and biochemical approaches to study the regulation, dynamics and functional niches of RNA maturation pathways and their implications in neurodegenerative diseases.

Daniel Zenklusen is an Associate Professor at the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada. His laboratory uses single molecule and super-resolution microscopy approaches to study different aspects of gene expression in single cells, including RNA transport and localization, lncRNAs function and mRNP organization.

Zusammenfassung

mRNA centric view on gene regulation

depicts the most recent findings in mRNA biology in a comprehensive manner

features new aspects of mRNA disease relations and mRNA structure

Inhaltsverzeichnis

Regulation of co-transcriptional mRNP assembly.- mRNA export through the NPC.- Roles of mRNA modifications in gene regulation.- Studying mRNPs using single molecule approaches.- Difference between mRNPs and lncRNAs?.- RNPs and/or sequence motives in mRNA localization.- mRNP structure.- New RNA binding proteins: mRNP composition.- Aggregation of repeats RNAs in neurodegenerative diseases.- mRNA structural organization and translation.- How to decide to make an mRNA - degradation.- Methods to study mRNP composition.- mRNA-DNA kisses - R-loops.- Forms of mRNA editing and their role in disease.

Details

Erscheinungsjahr:	2021
Fachbereich:	Therapie
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Reihe:	Advances in Experimental Medicine and Biology
Inhalt:	viii 312 S. 1 s/w Illustr. 29 farbige Illustr. 312 p. 30 illus. 29 illus. in color.
ISBN-13:	9783030314361
ISBN-10:	3030314367
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Oeffinger, Marlene Zenklusen, Daniel
Herausgeber:	Marlene Oeffinger/Daniel Zenklusen
Hersteller:	Springer Springer International Publishing AG Advances in Experimental Medicine and Biology
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 17 mm
Von/Mit:	Marlene Oeffinger (u. a.)
Erscheinungsdatum:	21.01.2021
Gewicht:	0,555 kg