Introduction; American political economy: a framework and agenda for research Jacob S. Hacker, Alexander Hertel-Fernandez, Paul Pierson, and Kathleen Thelen; Part I. Political Arenas and Actors: 1. Hurdles to shared prosperity: congress, parties, and the national policy process in an era of inequality Nathan J. Kelly and Jana Morgan; 2. The role of the law in the American political economy K. Sabeel Rahman and Kathleen Thelen; 3. Collective action, law, and the fragmented development of the American labor movement Alexander Hertel-Fernandez; Part II. Race, Space, and Governance: 4. Racial inequality, market inequality, and the American political economy Chloe Thurston; 5. The production of local inequality: race, class, and land use in American cities Jessica Trounstine; 6. The city re-centered? Local inequality mitigation in the twenty-first century Thomas K. Ogorzalek; 7. The political economies of red states Jacob M. Grumbach, Jacob S. Hacker, and Paul Pierson; Part III. Corporate Power and Concentration: 8. Mo' patents, mo' problems: corporate strategy, structure and profitability in America's political economy Herman Mark Schwartz; 9. Asset manager capitalism as a corporate governance regime Benjamin Braun; 10. Labor market power in the American political economy Suresh Naidu; Part IV. The American Knowledge Economy: 11. The United States as radical innovation driver: the politics of declining dominance? David Soskice; 12. Public investment in the knowledge economy Lucy Barnes; 13. Concentration and commodification: the political economy of post-industrialism in America and beyond Ben Ansell and Jane Gingrich; 14. The American political economy confronts covid-19 Jacob S. Hacker, Alexander Hertel-Fernandez, Paul Pierson, and Kathleen Thelen.