TABLE OF CONTENTS

Preface

Prologue

Part I – Alois & Auguste (and a bit of Oskar)

Chapter 1 – Dr Hoffmann’s vision

Chapter 2 – Mrs Deter

Chapter 3 – Alois Alzheimer

Chapter 4 – Munich via Heidelberg

Chapter 5 – 1906

Chapter 6 – The Tübingen aftermath

Chapter 7 – Fischer’s disease

Chapter 8 – Alzheimer’s legacy

Part I – Summary

Part II – Memory and Space

Chapter 9 – ‘You are not my type’

Chapter 10 – The art of memory

Chapter 11 – ‘Secret’ memory techniques

Chapter 12 – ‘Attention!’”

Chapter 13 – ‘Enter the seahorse’

Chapter 14 – Encoding, storage, retrieval

Chapter 15 – ‘It’s all about access’

Chapter 16 – The imaginary Mrs A

Chapter 17 – Spatial Disorientation

Chapter 18 – ‘Lost in space’

Part II – Summary

Part III – Amyloid and Tau

Chapter 19 – Glorious proteins

Chapter 20 – Amyloid

Chapter 21 – Beta-amyloid formation

Chapter 22 – ‘Location, location, location… and timing’

Chapter 23 – Tau

Chapter 24 – ‘Who ordered all the phosphate?’

Chapter 25 – Tau ‘infection’

Chapter 26 – Amyloid versus Tau

Chapter 27 – The ‘emergence’ of the disease

Chapter 28 – Biomarker technology

Chapter 29 – Amyloid treatment approaches

Decreasing beta-amyloid production

Prevention of beta-amyloid accumulation

Increase of beta-amyloid removal

Chapter 30 – Tau treatment approaches

Decrease of overall tau

Decrease of tau phosphorylation

Decrease phosphorylated tau accumulation

Increase phosphorylated tau removal

Chapter 31 – Why have drug trials failed so far?

Phase I

Phase II

Phase III

Part III – Summary

Part IV – Genetics and lifestyle

Chapter 32 – Genetics 101

Chapter 33 – Familial Alzheimer’s disease

APP

PSEN

MAPT

Chapter 34 – ‘Modifiable’ risk genes

APOE

TREM2

Chapter 35 – A word on genetic testing

Chapter 36 – Non-modifiable lifestyle factors

Age

Education

Hearing loss

Chapter 37 – Modifiable lifestyle factors

Diabetes, hypertension and obesity

Physical activity

Diet and nutrition

Sleep

Other modifiable lifestyle risk factors

Part IV – Summary

Part V – Rarer forms of Alzheimer’s disease

Chapter 38 – Frontal variant Alzheimer’s disease

Chapter 39 – Posterior Cortical Atrophy

Chapter 40 – Logopenic variant primary progressive aphasia

Chapter 41 – Corticobasal syndrome

Chapter 42 – A final word on the rarer forms of Alzheimer’s disease

Part V – Summary

Epilogue

Further country specific links (English language)

Index