Stochastic Chemical Reaction Systems in Bi...

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Beschreibung

This book provides an introduction to the analysis of stochastic dynamic models in biology and medicine. The main aim is to offer a coherent set of probabilistic techniques and mathematical tools which can be used for the simulation and analysis of various biological phenomena. These tools are illustrated on a number of examples. For each example, the biological background is described, and mathematical models are developed following a unified set of principles. These models are then analyzed and, finally, the biological implications of the mathematical results are interpreted. The biological topics covered include gene expression, biochemistry, cellular regulation, and cancer biology. The book will be accessible to graduate students who have a strong background in differential equations, the theory of nonlinear dynamical systems, Markovian stochastic processes, and both discrete and continuous state spaces, and who are familiar with the basic concepts of probability theory.

Über den Autor

Hong Qian is the Olga Jung Wan Endowed Professor of Applied Mathematics at the University of Washington, Seattle, USA. He received his B.A. in Astrophysics from Peking University, his Ph.D. in Biochemistry from Washington University in St. Louis, and worked as postdoctoral researcher in biophysical chemistry and mathematical biology at the University of Oregon and the California Institute of Technology. He was elected Fellow of the American Physical Society in 2010. Professor Qian's current research focuses on mathematical representations and the physical understanding of biological systems, especially in terms of stochastic mathematics and nonequilibrium statistical physics.

Hao Ge is an Associate Professor at the Beijing International Center for Mathematical Research and the Biomedical Pioneering Innovation Center of Peking University, Beijing, China. He received both his B.A. and Ph.D. in Probability and Statistics from Peking University, and worked as lecturerand associate professor at Fudan University from 2008 to 2011. He was a visiting scholar in the Department of Chemistry and Chemical Biology at Harvard University during 2010-2011. Professor Ge's main research interest is in the stochastic mathematics of nonequilibrium biophysics, biomathematics and biostatistics.

Zusammenfassung

Provides a systematic mathematical treatment of biological population dynamics in terms of probability theory

Introduces a new theoretical framework for nonequilibrium statistical physics with applications to biology

Offers a coherent approach to biophysics and physical chemistry based on stochastic kinetic models

Inhaltsverzeichnis

1. Introduction.- Part I Essentials of Deterministic and Stochastic Chemical Kinetics: 2. Kinetic Rate Equations and the Law of Mass Action.- 3. Probability Distribution and Stochastic Processes.- 4. Large Deviations and Kramers' rate formula.- 5. The Probabilistic Basis of Chemical Kinetics.- 6. Mesoscopic Thermodynamics of Markov Processes.- 7. Emergent Macroscopic Chemical Thermodynamics.- 8. Phase Transition and Mesoscopic Nonlinear Bistability.- Part III Stochastic Kinetics of Biochemical Systems and Processes: 9. Classic Enzyme Kinetics-The Michaelis-Menten and Briggs-Haldane Theories.- 10. Single-Molecule Enzymology and Driven Biochemical Kinetics with Chemostat.- 11. Stochastic Linear Reaction Kinetic Systems.- 12. Nonlinear Stochastic Reaction Systems with Simple Examples.- 13. Kinetics of the Central Dogma of Molecular Cell Biology.- 14. Stochastic Macromolecular Mechanics and Mechanochemistry.- Part IV Epilogue: Beyond Chemical Reaction Kinetics: 15. Landscape, Attractor-State Switching, and Differentiation.- 16. Nonlinear Stochastic Dynamics: New Paradigm and Syntheses.- References.- Index.

Details

Erscheinungsjahr:	2021
Fachbereich:	Allgemeines
Genre:	Mathematik
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Reihe:	Lecture Notes on Mathematical Modelling in the Life Sciences
Inhalt:	xxii 351 S. 23 s/w Illustr. 26 farbige Illustr. 351 p. 49 illus. 26 illus. in color.
ISBN-13:	9783030862510
ISBN-10:	3030862518
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Autor:	Ge, Hao Qian, Hong
Auflage:	1st ed. 2021
Hersteller:	Springer International Publishing Springer International Publishing AG Lecture Notes on Mathematical Modelling in the Life Sciences
Maße:	235 x 155 x 21 mm
Von/Mit:	Hao Ge (u. a.)
Erscheinungsdatum:	19.10.2021
Gewicht:	0,569 kg

Artikel-ID: 120418202