Sleep-Wake Neurobiology and Pharmacology

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Beschreibung

This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions.
The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.[...]

Zusammenfassung

First Handbook of Experimental Pharmacology on sleep and wakefulness, in which the pharmacology of sleep is discussed very much in the context of current knowledge of sleep function, its neuroanatomical and neurochemical bases, and including circadian rhythmicity

Powerful state-of-the-art methodologies are covered, such as optogenetics and designer receptor manipulations

Sleep- and wake-promoting compounds are not discussed in isolation, but within a single volume, which helps the understanding of their interrelationships

Inhaltsverzeichnis

Part 1.Basic Principles.- 1. The Function(s) of Sleep.- 2. Neuroanatomical and Neurochemical Bases of Vigilance States.- 3. Omics Approaches in Sleep-Wake Regulation.- 4. The Role of Glia in Sleep Regulation and Function.- 5. Sleep- and Wake-Like States in Small 1 Networks In Vivo and In Vitro.- Part 2. Optogenetics and Pharmacogenetics.- 6. Optogenetic Dissection of Sleep-Wake States In Vitro and In Vivo.- 7. Pharmacosynthetic Deconstruction of Sleep-wake Circuits in the Brain.- 8. Clinical and Experimental Human Sleep-Wake Pharmacogenetics.- Part 3. Sleep-Wake Pathologies.- 9. Clinical Sleep-Wake Disorders I: Focus on Hypersomnias and Movement Disorders During Sleep.- 10. Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders.- Part 4. Current and New Targets, and Therapeutic Prospects.- 11. GABA Receptors and the Pharmacology of Sleep.- 12. Advances of Melatonin-Based Therapies in the Treatment of Disturbed Sleep and Mood.- 13. Dopamine and Wakefulness: Pharmacology, Genetics, and Circuitry.- 14. Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood.- 15. Adenosine and Sleep.- Part 5. Outlook.- 16. Adenosine and Sleep.- 17. Functional Interactions Between Sleep and Circadian Rhythms in Learning and Learning Disabilities.- 18. Sleep Physiology, circadian rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics.

Details

Erscheinungsjahr:	2019
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Reihe:	Handbook of Experimental Pharmacology
Inhalt:	x 481 S. 14 s/w Illustr. 42 farbige Illustr. 481 p. 56 illus. 42 illus. in color.
ISBN-13:	9783030112707
ISBN-10:	3030112705
Sprache:	Englisch
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Dijk, Derk-Jan Landolt, Hans-Peter
Herausgeber:	Hans-Peter Landolt/Derk-Jan Dijk
Auflage:	1st ed. 2019
Hersteller:	Springer International Publishing Handbook of Experimental Pharmacology
Maße:	241 x 160 x 32 mm
Von/Mit:	Derk-Jan Dijk (u. a.)
Erscheinungsdatum:	19.09.2019
Gewicht:	0,898 kg

Artikel-ID: 115077538

Zusammenfassung

Powerful state-of-the-art methodologies are covered, such as optogenetics and designer receptor manipulations

Sleep- and wake-promoting compounds are not discussed in isolation, but within a single volume, which helps the understanding of their interrelationships

Inhaltsverzeichnis

Details

Erscheinungsjahr:	2019
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Reihe:	Handbook of Experimental Pharmacology
Inhalt:	x 481 S. 14 s/w Illustr. 42 farbige Illustr. 481 p. 56 illus. 42 illus. in color.
ISBN-13:	9783030112707
ISBN-10:	3030112705
Sprache:	Englisch
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Dijk, Derk-Jan Landolt, Hans-Peter
Herausgeber:	Hans-Peter Landolt/Derk-Jan Dijk
Auflage:	1st ed. 2019
Hersteller:	Springer International Publishing Handbook of Experimental Pharmacology
Maße:	241 x 160 x 32 mm
Von/Mit:	Derk-Jan Dijk (u. a.)
Erscheinungsdatum:	19.09.2019
Gewicht:	0,898 kg