Resilience and Success charts the education and career trajectories of African American women scientists and sheds light as to why young African American females drop off the science map in high school. It constructs a story about the map, which includes exits, entrances and turns. This phenomenon was influenced by cultural and socio-economic issues; class, race relations and racial biases; geography and most important, opportunities and serendipity. None of the roads were smooth as these African American women followed in the footsteps of those who had gone before them. It is critical for young African American female students to know that they have a passion and sense of curiosity befitting a future scientist. The stories of these women serve as a model for the way families, teachers, counselors, community activists and policy makers can participate in developing a new generation of African American women scientists.