Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA

Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UK

David Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada

List of Contributors ix

1 Basic Principles Underlying Coagulation 1
Dougald M. Monroe

2 Laboratory Tests of Hemostasis 12
Steve Kitchen and Michael Makris

3 Molecular Diagnostic Approaches to Hemostasis 27
Paula James and David Lillicrap

4 Tests of Platelet Function 42
Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison

5 Evaluation of the Bleeding Patient 63
Alice Ma and Marshall Mazepa

6 Hemophilia A and B 79
Rhona M. Maclean and Michael Makris

7 Von Willebrand disease 94
Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero

8 The Rarer Inherited Coagulation Disorders 113
Paula H.B. Bolton¿Maggs, Jonathan Wilde and Gillian N. Pike

9 Acquired Inhibitors of Coagulation 124
Riitta Lassila and Elina Armstrong

10 Quantitative Platelet Disorders 134
Riten Kumar and Walter H.A. Kahr

11 Qualitative Platelet Disorders 160
Eti A. Femia Gian Marco Podda and Marco Cattaneo

12 Disseminated Intravascular Coagulation 172
Raj S. Kasthuri and Nigel S. Key

13 Thrombotic Microangiopathies 183
Marie Scully and David Kavanagh

14 Venous Thromboembolism 195
Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon

15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210
Brandi Reeves and Stephan Moll

16 Arterial Thrombosis 229
R. Campbell Tait and Catherine N. Bagot

17 Anticoagulation: Heparins and Vitamin K Antagonists 240
Gualtiero Palareti and Benilde Cosmi

18 The Direct Oral Anticoagulants 253
David A. Garcia, Mark A. Crowther and Walter Ageno

19 Antiphospholipid Syndrome 269
Henry G. Watson and Mark Crowther

20 Cardiovascular Medicine 282
Sreekanth Vemulapalli and Richard C. Becker

21 Cardiothoracic Surgery 299
Denise O'Shaughnessy and Ravi Gill

22 Neurology 314
Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang

23 Hepatology 329
Lara N. Roberts, Raj K. Patel and Roopen Arya

24 Nephrology 340
Vimal K. Derebail and Thomas L. Ortel

25 Oncology 355
Anna Falanga and Marina Marchetti

26 Obstetrics, Contraception, and Estrogen Replacement 379
Amy Webster and Sue Pavord

27 Pediatrics 393
Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte

28 Intensive and Critical Care 414
Beverley J. Hunt

29 Transfusion 433
Adrian Copplestone

Appendix 1 Reference Ranges 444
Steve Kitchen and Michael Makris

Index 452