A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci, Emeritus Professor of Haematology at University College London, London, UK.

Douglas R. Higgs, MD, FRCP, FRS, Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

David Keeling, Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK.

Atul B. Mehta MA, MD, FRCP, FRC Path, Consultant Haematologist & Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK.

Contributor List vii Preface to the Seventh Edition x Preface to the First Edition xi 1 Stem cells and haemopoiesis 1Emma de Pater, Elaine Dzierzak 2 Erythropoiesis 11Douglas R Higgs, Noémi Roy, Deborah Hay 3 Iron metabolism, iron deficiency and disorders of haem synthesis 21
Clara Camaschella, A Victor Hoffbrand, Chaim Hershko 4 Iron overload 40Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini 5 Megaloblastic anaemia 53A Victor Hoffbrand 6 Haemoglobin and the inherited disorders of globin synthesis 72Swee Lay Thein, David Rees 7 Sickle cell disease 98Anne Marsh, Elliott P Vichinsky 8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114Paola Bianchi, Narla Mohandas 9 Acquired haemolytic anaemias 138Modupe O Elebute, Rachel Kesse-Adu 10 Inherited aplastic anaemia/bone marrow failure syndromes 156Inderjeet S Dokal 11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174Judith CW Marsh, Austin G Kulasekararaj, Neal S Young, Peter Hillmen 12 Red cell immunohaematology 195Geoff Daniels, Marcela Contreras, Shubha Allard 13 Clinical blood transfusion 214Shubha Allard, Marcela Contreras 14 Phagocytes 246John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman 15 Lysosomal storage disorders 270Atul B Mehta, Derralynn A Hughes 16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278Paul Moss, Mark Drayson 17 The spleen 303Paul Moss 18 The molecular basis of haematological malignancies 314Niccolo Bolli, George Vassiliou 19 Laboratory diagnosis of haematological neoplasms 332Torsten Haferlach, Barbara J Bain 20 Acute myeloid leukaemia 352Alan K Burnett, David Grimwade 21 Adult acute lymphoblastic Llukaemia 371Clare J Rowntree, Adele K Fielding 22 Childhood acute lymphoblastic leukaemia 384Ajay Vora 23 Supportive care in the management of leukaemia 399Eliza Gil, Vanya Gant, Panagiotis Kottaridis 24 Chronic myeloid leukaemia 419David TO Yeung, Timothy P Hughes 25 The myelodysplastic syndromes 438Kavita Raj, Ghulam J Mufti 26 Myeloproliferative neoplasms 474Peter J Campbell, Claire Harrison, Anthony R Green 27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500Emili Montserrat, Peter Hillmen 28 T-cell lymphoproliferative disorders 524Pier Luigi Zinzani, Alessandro Broccoli 29 Multiple myeloma 537Jesús San-Miguel, Joan Bladé 30 Amyloidosis 562Simon DJ Gibbs, Philip N Hawkins 31 The classification of lymphomas: updating the WHO classification 575Elias Campo, Stefano A Pileri 32 Hodgkin lymphoma 601Piers Blombery, David Linch 33 Non-Hodgkin lymphoma: low grade 614William Townsend, Robert Marcus 34 Non-Hodgkin lymphoma: high grade 631Jessica Okosun, Kate Cwynarski 35 Stem cell transplantation 651Charles Craddock, Ronjon Chakraverty 36 Normal haemostasis 676Keith Gomez, John H McVey 37 The vascular function of platelets 699Stephen P Watson, Neil V Morgan, Paul Harrison 38 Haemophilia and Von Willebrand disease 715Michael A Laffan, K John Pasi 39 Rare inherited coagulation disorders 733Flora Peyvandi, Marzia Menegatti 40 Acquired coagulation disorders 743Peter W Collins, Jecko Thachil, Cheng-Hock Toh 41 Congenital platelet disorders 761Maurizio Margaglione, Paul RJ Ames 42 Primary immune thrombocytopenia 773Drew Provan, Adrian C Newland 43 Thrombotic thrombocytopenic purpura and haemolytic-uraemic syndrome (congenital and acquired) 783Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla 44 Heritable thrombophilia 795Trevor Baglin, David Keeling 45 Acquired venous thrombosis 809Beverley J Hunt, Henry G Watson 46 Antithrombotic agents 820Trevor Baglin, David Keeling 47 Management of venous thromboembolism 830Trevor Baglin, David Keeling 48 Haematologicalaspectsofsystemicdisease 838A Victor Hoffbrand, Atul B Mehta 49 Haematological aspects of tropical diseases 854Imelda Bates, Ivy Ekem 50 Neonatal haematology 870Irene Roberts, Subarna Chakravorty 51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885 Index 888