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Cover: 9789400957800 | Organic Acids in Man | R. Chalmers | Taschenbuch | Paperback | xiii
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Organic Acids in Man
Analytical Chemistry, Biochemistry and Diagnosis of the Organic Acidurias
Taschenbuch von R. Chalmers
Sprache: Englisch

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Beschreibung
The writing of this book was prompted by the need for a comprehensive of current data on organic acids suitable for both newcomers and collection established researchers in this field. The only previous text of the kind was the excellent review by Nordmann and Nordmann (1961), and at that time the main method of analysis was paper chromatography with liquid chromatography being used in a limited way. Only three diseases in which organic acids accumulate were known (primary hyperoxaluria, phenylketonuria and alcaptonuria). Since then, with the development of gas chromatography and mass spectrometry, and the further development ofliquid chromatography, knowledge concerning the nature of the organic acids in physiological fluids has been greatly extended. At the same time, the number of organic acidurias has increased dramatically, there being now some 40-50 known diseases of this type. During the past 15 years or so, there have been several reviews, dealing with either specific diseases or groups of diseases (Gompertz, 1972, 1974; Tanaka, 1975), or presenting the proceedings of symposia (Stern and Toothill, 1972) or workshops (Marner et al. , 1974). This present text deals comprehensively and in detail with the organic acids in human physiological fluids in health and in disease states, and is particularly concerned with the methods necessary for their separation, determination and indentification.
The writing of this book was prompted by the need for a comprehensive of current data on organic acids suitable for both newcomers and collection established researchers in this field. The only previous text of the kind was the excellent review by Nordmann and Nordmann (1961), and at that time the main method of analysis was paper chromatography with liquid chromatography being used in a limited way. Only three diseases in which organic acids accumulate were known (primary hyperoxaluria, phenylketonuria and alcaptonuria). Since then, with the development of gas chromatography and mass spectrometry, and the further development ofliquid chromatography, knowledge concerning the nature of the organic acids in physiological fluids has been greatly extended. At the same time, the number of organic acidurias has increased dramatically, there being now some 40-50 known diseases of this type. During the past 15 years or so, there have been several reviews, dealing with either specific diseases or groups of diseases (Gompertz, 1972, 1974; Tanaka, 1975), or presenting the proceedings of symposia (Stern and Toothill, 1972) or workshops (Marner et al. , 1974). This present text deals comprehensively and in detail with the organic acids in human physiological fluids in health and in disease states, and is particularly concerned with the methods necessary for their separation, determination and indentification.
Inhaltsverzeichnis
1 Introduction.- References to Preface and Chapter 1.- I: Methods.- 2 Extraction of Organic Acids from Physiological Fluids.- 3 Derivatives of Organic Acids.- 4 Separation, Quantification and Identification.- 5 Gas Chromatography-Mass Spectrometry.- 6 Volatile Carboxylic Acids.- References to Part I.- II: Organic Acids in Physiological Fluids from Normal Subjects.- 7 Organic Acids in Blood and Urine from Normal Healthy Adults and Children.- 8 Organic Acids in Physiological Fluids Other than Urine and Blood.- References to Part II.- III: Organic Acids in Human Metabolic Diseases (The Organic Acidurias).- 9 Organic Acids in the Study of Metabolic Diseases.- 10 Disorders of Branched-Chain Amino Acid Metabolism.- 11 Disorders of Propionate and Methylmalonate Metabolism.- 12 Specific Causes of Congenital Keto Acidosis in Infants.- 13 Disorders of l-Lysine Metabolism.- 14 The Dicarboxylic Acidurias.- 15 Congenital Lactic Acidurias and Disorders of Pyruvate Metabolism.- 16 Organic Acidurias due to Disorders in Other Metabolic Pathways.- Appendix of Mass-Spectrometric and Gas-Chromatographic Data.
Details
Erscheinungsjahr: 2011
Fachbereich: Allgemeines
Rubrik: Sozialwissenschaften
Medium: Taschenbuch
Inhalt: xiii
523 S.
ISBN-13: 9789400957800
ISBN-10: 9400957807
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Chalmers, R.
Auflage: Softcover reprint of the original 1st ed. 1982
Hersteller: Springer Netherland
Springer Netherlands
Maße: 235 x 155 x 29 mm
Von/Mit: R. Chalmers
Erscheinungsdatum: 12.10.2011
Gewicht: 0,809 kg
Artikel-ID: 105626432
Inhaltsverzeichnis
1 Introduction.- References to Preface and Chapter 1.- I: Methods.- 2 Extraction of Organic Acids from Physiological Fluids.- 3 Derivatives of Organic Acids.- 4 Separation, Quantification and Identification.- 5 Gas Chromatography-Mass Spectrometry.- 6 Volatile Carboxylic Acids.- References to Part I.- II: Organic Acids in Physiological Fluids from Normal Subjects.- 7 Organic Acids in Blood and Urine from Normal Healthy Adults and Children.- 8 Organic Acids in Physiological Fluids Other than Urine and Blood.- References to Part II.- III: Organic Acids in Human Metabolic Diseases (The Organic Acidurias).- 9 Organic Acids in the Study of Metabolic Diseases.- 10 Disorders of Branched-Chain Amino Acid Metabolism.- 11 Disorders of Propionate and Methylmalonate Metabolism.- 12 Specific Causes of Congenital Keto Acidosis in Infants.- 13 Disorders of l-Lysine Metabolism.- 14 The Dicarboxylic Acidurias.- 15 Congenital Lactic Acidurias and Disorders of Pyruvate Metabolism.- 16 Organic Acidurias due to Disorders in Other Metabolic Pathways.- Appendix of Mass-Spectrometric and Gas-Chromatographic Data.
Details
Erscheinungsjahr: 2011
Fachbereich: Allgemeines
Rubrik: Sozialwissenschaften
Medium: Taschenbuch
Inhalt: xiii
523 S.
ISBN-13: 9789400957800
ISBN-10: 9400957807
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Chalmers, R.
Auflage: Softcover reprint of the original 1st ed. 1982
Hersteller: Springer Netherland
Springer Netherlands
Maße: 235 x 155 x 29 mm
Von/Mit: R. Chalmers
Erscheinungsdatum: 12.10.2011
Gewicht: 0,809 kg
Artikel-ID: 105626432
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