Nicotinic Acetylcholine Receptor Signaling...

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Beschreibung

This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

Über den Autor

Akinori Akaike

Department of Pharmacology, Kyoto University, Japan

Shun Shimohama

Department of Neurology, Sapporo Medical University School of Medicine, Japan

Yoshimi Misu

Graduate School of Medicine, Yokohama City University, Japan

Zusammenfassung

Summarizes and enriches understanding of the novel aspects of nicotinic acetylcholine receptor (nAChR) functions in the CNS

Professionals and scholars alike will find it a handy up-to-date overview of basic and clinical studies of nAChRs for the treatment of neurodegenerative diseases

This Open Access Book has an interdisciplinary appeal and will engage scholars in field of drug innovation

Inhaltsverzeichnis

1.Overview.- [...] vivo imaging of nicotinic acetylcholine receptors in the central nervous system.- 3.A new aspect of cholinergic transmission in the central nervous system.- 4.Nicotinic acetylcholine receptor signaling: roles in neuroprotection.- 5.Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection.- [...]/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans.- 7.Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders.- [...] of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer's and Parkinson's diseases.- 9.SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors.- 10.Removal of blood amyloid as a therapeutic strategy for Alzheimer's disease: the influence of smoking and nicotine.

Details

Erscheinungsjahr:	2018
Fachbereich:	Therapie
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	x 191 S. 38 s/w Illustr. 24 farbige Illustr. 191 p. 62 illus. 24 illus. in color.
ISBN-13:	9789811084874
ISBN-10:	9811084874
Sprache:	Englisch
Herstellernummer:	978-981-10-8487-4
Einband:	Gebunden
Redaktion:	Akaike, Akinori Misu, Yoshimi Shimohama, Shun
Herausgeber:	Akinori Akaike/Shun Shimohama/Yoshimi Misu
Auflage:	1st edition 2018
Hersteller:	Springer Singapore Springer Nature Singapore
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	241 x 160 x 16 mm
Von/Mit:	Akinori Akaike (u. a.)
Erscheinungsdatum:	13.04.2018
Gewicht:	0,514 kg

Artikel-ID: 111188662