PART 1 SCIENTIFIC PRINCIPLES OF RESPIRATORY MEDICINE

SECTION A Anatomy and Development of the Respiratory Tract

1. Anatomy

2. Lung Growth and Development

3. Alveolar Compartment

4. Airway Biology

5. Lung Mesenchyme

6. Vascular Biology

7. Lymphatic Biology

8. Regeneration and Repair

9. Genetics of Lung Disease

SECTION B Respiratory Physiology

10. Ventilation, Blood Flow, and Gas Exchange

11. Respiratory System Mechanics and Energetics

12. Acid-Base Balance

13. Aerosol and Drug Delivery

14. Pleural Physiology and Pathophysiology

SECTION C Defense Mechanisms and Immunology

15. Innate Immunity

16. Adaptive Immunity

17. Microbiome

PART 2 DIAGNOSIS AND EVALUATION OF RESPIRATORY DISEASE

SECTION D Diagnosis

18. History and Physical Examination

19. Microbiological Diagnosis of Lung Infection

20. Thoracic Radiology: Noninvasive Diagnostic Imaging

21. Thoracic Radiology: Invasive Diagnostic Imaging and Image-Guided Interventions

22. Pathology

23. Ultrasonography: Principles, and Basic Thoracic and Vascular Imaging

24. Ultrasonography: Advanced Applications and Procedures

25. Positron Emission Tomography

26. Diagnostic Bronchoscopy: Basic Techniques

27. Diagnostic Bronchoscopy: Advanced Techniques (EBUS and Navigational)

28. Therapeutic Bronchoscopy: Interventional Techniques

29. Thoracoscopy

30. Thoracic Surgery

SECTION E Evaluation

31. Pulmonary Function Testing: Physiologic and technical principles

32. Pulmonary Function Testing: Interpretation and Applications

33. Exercise Testing

34. Preoperative Evaluation

35. Evaluation of Respiratory Impairment and Disability

PART 3 CLINICAL RESPIRATORY MEDICINE

SECTION F Evaluation of Common Presentations of Respiratory Disease

36. Dyspnea

37. Cough

38. Chest Pain

39. Wheezing and Stridor

40. Hemoptysis

41. Pulmonary Nodule

42. Positive Screening Test for Tuberculosis

43. Aspiration

44. Hypoxemia

45. Hypercarbia

SECTION G Infectious Diseases of the Lungs

46. Community-Acquired Pneumonia

46a. COVID-19

47. Influenza

48. Hospital-Acquired Pneumonia

49. Ventilator-Associated Pneumonia

50. Lung Abscess

51. Tuberculosis: Epidemiology and Prevention

52. Tuberculosis: Pathogenesis and immunity

53. Tuberculosis: Clinical Manifestations and Diagnosis

54. Tuberculosis: Treatment of Drug-Susceptible and Drug-Resistant

55. Nontuberculous Mycobacterial Infections

56. Fungal Infections: Endemic

57. Fungal Infections: Opportunistic

58. Parasitic Infections

59. Outbreaks, Epidemics, and Bioterrorism

SECTION H Obstructive Diseases

60. Asthma: Pathogenesis and Phenotypes

61. Asthma and Obesity

62. Asthma: Diagnosis and Management

63. COPD: Pathogenesis and Natural History

64. COPD: Diagnosis and Management

65. Smoking Hazards: Cigarettes, Vaping, Marijuana

66. Smoking Cessation

67. Cystic Fibrosis: Pathogenesis and Epidemiology

68. Cystic Fibrosis: Diagnosis and Management

69. Bronchiectasis

70. Upper Airway Disorders

71. Large Airway Disorders

72. Bronchiolitis

SECTION I Neoplasms of the Lung

73. Lung Cancer: Molecular Biology and Targets

74. Lung Cancer: Epidemiology

75. Lung Cancer: Screening

76. Lung Cancer: Diagnosis and Staging

77. Lung Cancer: Treatment

78. Rare Primary Lung Tumors

79. Metastatic Malignant Tumors

80. Benign Lung Tumors

SECTION J Disorders of the Pulmonary Circulation

81. Pulmonary Thromboembolism: Presentation and Diagnosis

82. Pulmonary Thromboembolism: Prophylaxis and Treatment

83. Pulmonary Hypertension: General Approach

84. Pulmonary Arterial Hypertension: Group 1

85. Pulmonary Hypertension due to Lung Disease: Group 3

86. Pulmonary Hypertension due to Chronic Thromboembolic Disease: Group 4

87. Pulmonary Vasculitis

88. Pulmonary Vascular Anomalies

SECTION K Infiltrative and Interstitial Lung Diseases

89. Idiopathic Pulmonary Fibrosis

90. Nonspecific Interstitial Pneumonitis and Other Idiopathic Interstitial Pneumonias

91. Hypersensitivity Pneumonitis

92. Connective Tissue Diseases

93. Sarcoidosis

94. Diffuse Alveolar Hemorrhage

95. Pulmonary Langerhans Cell Histiocytosis and other Rare Diffuse Infiltrative Lung Diseases

96. Eosinophilic Lung Diseases

97. Lymphangioleiomyomatosis

98. Pulmonary Alveolar Proteinosis Syndromes

99. Drug-Induced Pulmonary Disease

SECTION L Environmental and Occupational Hazards

100. Asthma in the Workplace

101. Pneumoconioses

102. Indoor and Outdoor Air Pollution

103. Acute Responses to Toxic Exposures

104. Trauma and Blast Injuries

105. High Altitude

106. Air Travel

107. Diving Medicine

SECTION M Disorders of the Pleura

108. Pleural Effusions

109. Pleural Infections

110. Pneumothorax

111. Chylothorax

112. Pleural Fibrosis and Unexpandable Lung

113. Hemothorax

114. Pleural Malignancy

SECTION N Disorders of the Mediastinum

115. Mediastinal Tumors and Cysts

116. Mediastinitis and Fibrosing Mediastinitis

SECTION O Disorders of Sleep and Control of Breathing

117. Control of Breathing and Upper Airways During Sleep

118. Consequences of Sleep Disruption

119. Sleep-Disordered Breathing: General Approach

120. Obstructive Sleep Apnea

121. Central Sleep Apnea

122. Sleep-Disordered Breathing: Treatment

SECTION P Respiratory Manifestations of Extrapulmonary Disorders

123. Pulmonary Complications of HIV Infection

124. Pulmonary Complications of Primary Immunodeficiencies

125. Pulmonary Complications of Stem Cell and Solid Organ Transplantation

126. Pulmonary Complications of Abdominal Diseases

127. Pulmonary Complications of Hematologic Diseases

128. Pulmonary Complications of Endocrine Diseases

129. The Lungs in Obstetric and Gynecologic Diseases

130. The Respiratory System and Neuromuscular Diseases

131. The Respiratory System and Chest Wall Diseases

SECTION Q Management of Respiratory Failure

132. Acute Ventilatory Failure

133. Pulmonary Edema

134. Acute Respiratory Distress Syndrome

135. Mechanical Ventilation

136. Noninvasive Support of Ventilation

137. Noninvasive Support of Oxygenation

138. Extracorporeal Support of Gas Exchange

139. Pulmonary Rehabilitation

140. Lung Transplantation

141. End-of-Life Care in Respiratory Failure

Appendix