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Beschreibung
This fully revised and expanded Third Edition of Ionic Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. Ionic Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognised authoritative overview of this field used by all neuroscientists.
This fully revised and expanded Third Edition of Ionic Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. Ionic Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognised authoritative overview of this field used by all neuroscientists.
Über den Autor
Bertil Hille is Professor in the Department of Physiology and Biophysics at the University of Washington. He graduated summa cum laude from Yale University with a B.S. in Zoology, and earned a Ph.D. in Life Sciences at The Rockefeller University. Dr. Hille then did postdoctoral work in the laboratories of A. L. Hodgkin and R. D. Keynes. He was elected to the National Academy of Sciences in 1986, and has received numerous awards, including: the Third Annual Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1990); the Columbia University Louisa Gross Horwitz Prize for Biology or Biochemistry (1996, shared with Clay Armstrong); and the Albert Lasker Basic Medical Research Award (1999, jointly with Clay Armstrong and Roderick MacKinnon). A cell physiologist, neurobiologist, and educator, Dr. Hille works on ion channel biophysics, signaling by modulatory neurotransmitters, and intracellular calcium dynamics.
Zusammenfassung
Written to be accessible to any biological student Suitable for Undergraduates and Postgraduates Authoritative overview of this field Thoroughly revised and expanded to include latest research
Inhaltsverzeichnis
- 1. Introduction
- PART I: Description of Channels
- 2. Classical Biophysics of the Squid Giant Axon
- 3. The Superfamily of Voltage-Gated Channels
- 4. Voltage-Gated Calcium Channels
- 5. Potassium Channels and Chloride Channels
- 6. Ligand-Gated Channels of Fast Chemical Synapses
- 7. Modulation, Slow Synaptic Action, and Second Messengers
- 8. Sensory Transduction and Excitable Cells
- 9. Calcium Dynamics, Epithelial Transport, and Intercellular Coupling
- PART II: Principles and Mechanisms of Functions
- 10. Elementary Properties of Ions in Solution
- 11. Elementary Properties of Pores
- 12. Counting Channels and Measuring Fluctuations
- 13. Structure of Channel Proteins
- 14. Selective Permeability: Independence
- 15. Selective Permeability: Saturation and Binding
- 16. Classical Mechanisms of Block
- 17. Structure-Function Studies of Permeation and Block
- 18. Gating Mechanisms: Kinetic Thinking
- 19. Gating: Voltage Sensing and Inactivation
- 20. Modification of Gating in Voltage-Sensitive Channels
- 21. Cell Biology and Channels
- 22. Evolution and Origins
Details
| Erscheinungsjahr: | 2001 |
|---|---|
| Fachbereich: | Grundlagen |
| Genre: | Biologie |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Buch |
| Seiten: | 814 |
| ISBN-13: | 9780878933211 |
| ISBN-10: | 0878933212 |
| Einband: | Gebunden |
| Autor: | Hille, Bertil |
| Hersteller: |
Sinauer Associates Inc.
Oxford University Press Inc |
| Maße: | 241 x 204 x 36 mm |
| Von/Mit: | Bertil Hille |
| Erscheinungsdatum: | 30.08.2001 |
| Gewicht: | 1,524 kg |
Über den Autor
Bertil Hille is Professor in the Department of Physiology and Biophysics at the University of Washington. He graduated summa cum laude from Yale University with a B.S. in Zoology, and earned a Ph.D. in Life Sciences at The Rockefeller University. Dr. Hille then did postdoctoral work in the laboratories of A. L. Hodgkin and R. D. Keynes. He was elected to the National Academy of Sciences in 1986, and has received numerous awards, including: the Third Annual Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1990); the Columbia University Louisa Gross Horwitz Prize for Biology or Biochemistry (1996, shared with Clay Armstrong); and the Albert Lasker Basic Medical Research Award (1999, jointly with Clay Armstrong and Roderick MacKinnon). A cell physiologist, neurobiologist, and educator, Dr. Hille works on ion channel biophysics, signaling by modulatory neurotransmitters, and intracellular calcium dynamics.
Zusammenfassung
Written to be accessible to any biological student Suitable for Undergraduates and Postgraduates Authoritative overview of this field Thoroughly revised and expanded to include latest research
Inhaltsverzeichnis
- 1. Introduction
- PART I: Description of Channels
- 2. Classical Biophysics of the Squid Giant Axon
- 3. The Superfamily of Voltage-Gated Channels
- 4. Voltage-Gated Calcium Channels
- 5. Potassium Channels and Chloride Channels
- 6. Ligand-Gated Channels of Fast Chemical Synapses
- 7. Modulation, Slow Synaptic Action, and Second Messengers
- 8. Sensory Transduction and Excitable Cells
- 9. Calcium Dynamics, Epithelial Transport, and Intercellular Coupling
- PART II: Principles and Mechanisms of Functions
- 10. Elementary Properties of Ions in Solution
- 11. Elementary Properties of Pores
- 12. Counting Channels and Measuring Fluctuations
- 13. Structure of Channel Proteins
- 14. Selective Permeability: Independence
- 15. Selective Permeability: Saturation and Binding
- 16. Classical Mechanisms of Block
- 17. Structure-Function Studies of Permeation and Block
- 18. Gating Mechanisms: Kinetic Thinking
- 19. Gating: Voltage Sensing and Inactivation
- 20. Modification of Gating in Voltage-Sensitive Channels
- 21. Cell Biology and Channels
- 22. Evolution and Origins
Details
| Erscheinungsjahr: | 2001 |
|---|---|
| Fachbereich: | Grundlagen |
| Genre: | Biologie |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Buch |
| Seiten: | 814 |
| ISBN-13: | 9780878933211 |
| ISBN-10: | 0878933212 |
| Einband: | Gebunden |
| Autor: | Hille, Bertil |
| Hersteller: |
Sinauer Associates Inc.
Oxford University Press Inc |
| Maße: | 241 x 204 x 36 mm |
| Von/Mit: | Bertil Hille |
| Erscheinungsdatum: | 30.08.2001 |
| Gewicht: | 1,524 kg |
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