Intrinsically Disordered Proteins Studied ...

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Beschreibung

This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research.
Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments.

Intrinsically Disordered Proteins Studied by NMR Spectroscopy provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Zusammenfassung

Focuses on Intrinsically Disordered Proteins studied by NMR Spectroscopy

Chapters written by partners of the Marie Curie Initial Training Network

The study of intrinsically disordered proteins has seen explosive growth over the past five to ten years

Includes supplementary material: [...]

Inhaltsverzeichnis

Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins.- Structure and Dynamics of Intrinsically Disordered Proteins.- NMR methods for the study of IDP structure, dynamics and interactions: general overview and practical guidelines.- Ensemble Calculation for IDPs Using NMR Parameters.- NMR Spectroscopic Studies of the Conformational Ensembles of Intrinsically Disordered Proteins.- Recombinant IDPs for NMR: Tips and Tricks.- Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an "Elephant and Blind Men" Situation.- Application of SAXS for the Structural Characterization of IDPs.- Bioinformatics Approaches for Predicting Disordered Protein Motifs.- Towards Understanding Protein Disorder In-Cell.- The Protein Ensemble Database.- Order and Disorder in the Replicative Complex of Paramyxoviruses.- Druggability of Intrinsically Disordered Proteins.- Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer's Disease.

Details

Erscheinungsjahr:	2015
Fachbereich:	Allgemeines
Genre:	Biologie , Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Naturwissenschaften & Technik
Medium:	Buch
Inhalt:	xiii 421 S. 13 s/w Illustr. 98 farbige Illustr. 421 p. 111 illus. 98 illus. in color.
ISBN-13:	9783319201634
ISBN-10:	3319201638
Sprache:	Englisch
Herstellernummer:	978-3-319-20163-4
Einband:	Gebunden
Redaktion:	Felli, Isabella C. Pierattelli, Roberta
Herausgeber:	Isabella C Felli/Roberta Pierattelli
Hersteller:	Springer Springer Nature Switzerland Springer International Publishing AG
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	241 x 160 x 28 mm
Von/Mit:	Isabella C. Felli (u. a.)
Erscheinungsdatum:	30.09.2015
Gewicht:	0,816 kg