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Cover: 9781588290472 | In Vitro Neurotoxicology | Principles and Challenges | Buch | Englisch
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In Vitro Neurotoxicology
Principles and Challenges
Buch von Evelyn Tiffany-Castiglioni
Sprache: Englisch

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Beschreibung
Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.
Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.
Zusammenfassung

Includes supplementary material: [...]

Inhaltsverzeichnis
In Vitro Neurotoxicology.- Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment.- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics.- In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis.- Role of Apoptosis in Neurotoxicology.- Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants.- Cell-Type Specific Responses of the Nervous System to Lead.- Effects of Toxicants on Neural Differentiation.- Impairment of Synaptic Function by Exposure to Lead.- Aggregating Brain Cell Cultures for Neurotoxicological Studies.- Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors.- Establishing In Vitro Models to Study Endogenous Neurotoxicants.
Details
Erscheinungsjahr: 2003
Fachbereich: Toxikologie
Genre: Medizin
Rubrik: Wissenschaften
Medium: Buch
Reihe: Methods in Pharmacology and Toxicology
ISBN-13: 9781588290472
ISBN-10: 1588290476
Sprache: Englisch
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Redaktion: Tiffany-Castiglioni, Evelyn
Hersteller: Humana Press
Humana Press Inc.
Methods in Pharmacology and Toxicology
Maße: 241 x 160 x 26 mm
Von/Mit: Evelyn Tiffany-Castiglioni
Erscheinungsdatum: 01.12.2003
Gewicht: 0,751 kg
Artikel-ID: 102398418
Zusammenfassung

Includes supplementary material: [...]

Inhaltsverzeichnis
In Vitro Neurotoxicology.- Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment.- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics.- In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis.- Role of Apoptosis in Neurotoxicology.- Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants.- Cell-Type Specific Responses of the Nervous System to Lead.- Effects of Toxicants on Neural Differentiation.- Impairment of Synaptic Function by Exposure to Lead.- Aggregating Brain Cell Cultures for Neurotoxicological Studies.- Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors.- Establishing In Vitro Models to Study Endogenous Neurotoxicants.
Details
Erscheinungsjahr: 2003
Fachbereich: Toxikologie
Genre: Medizin
Rubrik: Wissenschaften
Medium: Buch
Reihe: Methods in Pharmacology and Toxicology
ISBN-13: 9781588290472
ISBN-10: 1588290476
Sprache: Englisch
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Redaktion: Tiffany-Castiglioni, Evelyn
Hersteller: Humana Press
Humana Press Inc.
Methods in Pharmacology and Toxicology
Maße: 241 x 160 x 26 mm
Von/Mit: Evelyn Tiffany-Castiglioni
Erscheinungsdatum: 01.12.2003
Gewicht: 0,751 kg
Artikel-ID: 102398418
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