Human Epigenetics: How Science Works

Dekorationsartikel gehören nicht zum Leistungsumfang.

Sprache: Englisch

85,70 €*

inkl. MwSt.

Versandkostenfrei per Post / DHL

Lieferzeit 1-2 Wochen

Kategorien:

Der Artikel ist nicht in deutscher Sprache verfasst.
Die Sprache der Produktbeschreibung und Details kann in Englisch angegeben sein. Sollten Sie Verständnisprobleme haben, wenden Sie sich gerne an uns.

Beschreibung

The view ¿It¿s all in our genes and we cannot change it¿ developed in the past 150 years since Gregor Mendel¿s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer.

This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described.

The book represents an updated but simplified version of our textbook ¿Human Epigenomics¿ (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Über den Autor

Carsten Carlberg graduated in 1989 with a Ph.D. in Biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland), and docent at the University of Du¿sseldorf (Germany) he is since 2000 Full Professor of Biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg has projects on epigenome-wide effects of vitamin D on the human immune system.

Ferdinand Molnär received his Ph.D. in Biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor¿ ligand, ¿protein, and ¿DNA interactions. In 2018 he moved to the NazarbayevUniversity (Astana, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnär's interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease, and recombinant protein production.

Zusammenfassung

Is the first undergraduate textbook on epigenetics with a clear focus on humans

Links the "hot topic" epigenetics to numerous disciplines, such as embryogenesis, nutrition and neuroscience

Describes the impact of epigenetics in health and disease

Has a high ratio figures to text

Inhaltsverzeichnis

Introduction.- Chromatin and gene expression.- DNA methylation.- Histone modifications.- Chromatin modifying proteins and RNAs.- Embryogenesis and cellular differentiation.- Population epigenetics and aging.- Cancer epigenetics.- Neuroepigenetics.- Nutritional epigenetics.- Epigenetics of immune function.- Epigenome-environment interactions and their therapy.

Details

Erscheinungsjahr:	2019
Fachbereich:	Gentechnologie
Genre:	Biologie
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	xvi 153 S. 69 farbige Illustr. 153 p. 69 illus. in color.
ISBN-13:	9783030229061
ISBN-10:	3030229068
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Autor:	Molnár, Ferdinand Carlberg, Carsten
Auflage:	1st ed. 2019
Hersteller:	Springer International Publishing
Maße:	235 x 155 x 10 mm
Von/Mit:	Ferdinand Molnár (u. a.)
Erscheinungsdatum:	05.10.2019
Gewicht:	0,303 kg

Artikel-ID: 116615610