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Cover: 9783540261209 | Free-Radical-Induced DNA Damage and Its Repair | Clemens Sonntag | XX
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Free-Radical-Induced DNA Damage and Its Repair
A Chemical Perspective
Buch von Clemens Sonntag
Sprache: Englisch

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Beschreibung
The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell¿s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell¿s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Über den Autor

Born in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut für Strahlenchemie, Mülheim. After retirement continuing collaboration with the Leibniz-Institut für Oberflächenmodifizierung (IOM), Leipzig.

Zusammenfassung
Both chemists and molecular biologists will find this an invaluable reference work for the study of free radical induced DNA damage and its repair.
Inhaltsverzeichnis
Formation of Reactive Free Radicals in an Aqueous Environment.- The Hydroxyl Radical.- Hydrogen Atom and Hydrated Electron.- Inorganic Radicals.- Carbon-Centered Radicals.- Heteroatom-Centered Radicals.- Peroxyl Radicals.- Polymer Radicals.- Nucleobases, Nucleosides and Nucleotides.- Polynucleotides and Single-Stranded DNA Fragments.- DNA and Double-Stranded Oligonucleotides.- Methods.
Details
Erscheinungsjahr: 2005
Fachbereich: Biophysik
Genre: Biologie
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Seiten: 544
Inhalt: xx
523 S.
100 s/w Tab.
ISBN-13: 9783540261209
ISBN-10: 3540261206
Sprache: Englisch
Herstellernummer: 10672045
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Autor: Sonntag, Clemens
Auflage: 2006
Hersteller: Springer Berlin
Springer Berlin Heidelberg
Maße: 241 x 160 x 35 mm
Von/Mit: Clemens Sonntag
Erscheinungsdatum: 02.12.2005
Gewicht: 0,975 kg
preigu-id: 102305886
Über den Autor

Born in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut für Strahlenchemie, Mülheim. After retirement continuing collaboration with the Leibniz-Institut für Oberflächenmodifizierung (IOM), Leipzig.

Zusammenfassung
Both chemists and molecular biologists will find this an invaluable reference work for the study of free radical induced DNA damage and its repair.
Inhaltsverzeichnis
Formation of Reactive Free Radicals in an Aqueous Environment.- The Hydroxyl Radical.- Hydrogen Atom and Hydrated Electron.- Inorganic Radicals.- Carbon-Centered Radicals.- Heteroatom-Centered Radicals.- Peroxyl Radicals.- Polymer Radicals.- Nucleobases, Nucleosides and Nucleotides.- Polynucleotides and Single-Stranded DNA Fragments.- DNA and Double-Stranded Oligonucleotides.- Methods.
Details
Erscheinungsjahr: 2005
Fachbereich: Biophysik
Genre: Biologie
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Seiten: 544
Inhalt: xx
523 S.
100 s/w Tab.
ISBN-13: 9783540261209
ISBN-10: 3540261206
Sprache: Englisch
Herstellernummer: 10672045
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Autor: Sonntag, Clemens
Auflage: 2006
Hersteller: Springer Berlin
Springer Berlin Heidelberg
Maße: 241 x 160 x 35 mm
Von/Mit: Clemens Sonntag
Erscheinungsdatum: 02.12.2005
Gewicht: 0,975 kg
preigu-id: 102305886
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