Douglas C. Anthony, MD, PhD is Professor of Pathology and Laboratory Medicine, and Professor of Neurology at the Warren Alpert School of Medicine at Brown University. He received his BS in Chemical Engineering from Washington University in St. Louis, his PhD in Experimental Pathology and MD from Duke University, followed by residency, fellowships, and U.S. board certification in Pathology and Neuropathology.

Before assuming his position at Brown University, he was Assistant Professor of Pathology at Duke University, Associate Professor of Pathology at Harvard University, and Professor and Chair of Pathology and Anatomy at the University of Missouri and played a central leadership role in the educational and research programs in pathology and laboratory medicine at each institution. He has conducted research in cellular and molecular neurosciences with a focus on translational biology and diagnostic neuropathology. He has broad experience in mentoring and training students and junior faculty at the interface between clinical medicine and basic sciences, navigating the complex interfaces between the independent research lab and the clinical services of complex academic medical centers.

Dr. Anthony is the author of over 150 articles and has received multiple grants and awards for his research. He has served on multiple editorial boards and authored neuroscience sections in multiple editions of the Robbins and Cotran Pathologic Basis of Disease, and multiple prior editions of Escourolle and Poirier's Manual of Basic Neuropathology. He has served as President of the New England Society of Pathologists, President of the American Association of Neuropathologists, and Vice President of the International Society of Neuropathology.

Umberto De Girolami, MD, is Professor of Pathology at Harvard Medical School, and Neuropathologist at the Brigham and Women's Hospital in Boston. He received his BS in Chemistry and his MD from the University of Miami, followed by residency, fellowships, and U.S. board certification in Pathology and Neuropathology. He served as Professor of Pathology and Neurology at the University of Massachusetts Medical School before moving to Harvard Medical School and has held leadership positions in neuropathology at multiple Harvard-affiliated hospitals in Boston, including directing the Longwood neuropathology fellowship at Harvard Medical School. He is the author of over 130 publications and has received multiple grants and awards for his research. He has served on multiple editorial boards and was Associate Editor for Brain Pathology.

He has authored multiple books and is an author of neuroscience sections in multiple editions of the Robbins and Cotran Pathologic Basis of Disease, and multiple prior editions of Escourolle and Poirier's Manual of Basic Neuropathology. He has lectured throughout the world as Visiting Professor in China, Philippines, Korea, South America, South Africa, France, and Switzerland, and has served in leadership roles in the American Association of Neuropathologists, International Society of Neuropathology, President of the Boston Society of Neurology and Psychiatry.

Franck Bielle, MD, PhD, is Professor of Pathology at Sorbonne University in Paris, and a leader at the Paris Brain Institute of the research group focusing on the pathobiology of brain tumors. He earned his MS in Neuropharmacology, and PhD in Life Sciences at Pierre and Marie Curie University (UPMC), followed by MD, residency, and fellowships in pathology and neuropathology.

He has made outstanding contributions to the fields of neuropathology and neuro-oncology, authoring over 150 publications. His academic background includes an Inter-University Degree in medical pedagogy, and he has a strong commitment to medical education. He has received multiple grants and awards for his work in the pathology of brain tumors and is the lead on co-evolution of brain tumors and their microenvironment at the Paris Brain Institute.

Dr. Bielle plays an active role in numerous national and international scientific committees, including serving as the main coordinator of neuropathology for the European Network for the management of rare brain tumors (EURACAN). His collaborations span across continents, working with research teams in the Netherlands, France, Germany, and at the Dana Farber Cancer Institute in the US on mismatch repair deficiency in gliomas.

Danielle Seilhean, MD, PhD, is Professor of Pathology at Sorbonne University in Paris, and the head of the Raymond Escourolle Department of Neuropathology at Pitié-Salpêtrière Hospital. Her contributions to the field of neuropathology, particularly in the study of neurodegenerative diseases, have earned her international recognition and numerous prestigious awards. She began her studies at the University of Bordeaux and obtained her MD from Pierre & Marie Curie University (UPMC), with subsequent certifications in pathology and neuropathology. She obtained a PhD in neurosciences working on glial-neuronal interactions and neurodegenerative diseases, and has been recognized with Habilitation to Supervise Research (HDR) for supervising doctoral research, and holds diplomas in Health Ethics, Human Rights, and Morals from the Council of Europe and in Medical Education Sciences.

Working at the Paris Brain Institute (ICM) at Pitié-Salpêtrière, she has authored over 200 publications, and holds a patent for a novel orthobunyavirus related to human encephalitis. She has received numerous awards, including the Malakoff-Mederic Award for her contributions to research in multiple sclerosis and was honored with the Chevalier of the Legion of Honour (Légion d'Honneur), France's highest civilian distinction. She has served as President of the French Society of Neuropathology and has been a member of various scientific and editorial boards, also serving as Director of the International Exchange Programme and later as the Vice President for International Affairs at UPMC.

• Foreword by Allan H. Ropper


• Preface to Seventh Edition


• Contributors List


• Chapter 1: Basic Pathology of the Nervous System


• Danielle Seilhean, Matthew Torre, Gabor G. Kovacs, and Umberto De Girolami


• Chapter 2: Tumors of the Central Nervous System


• Franck Bielle, Sandro Santagata, and Keith L. Ligon


• Chapter 3: Central Nervous System Trauma


• Colin Smith and R. Ross Reichard


• Chapter 4: Vascular Disease


• Jean-Jacques Hauw, Harry V. Vinters, Pierre Amarenco, and Umberto De Girolami


• Chapter 5: Infections of the Central Nervous System


• Fabrice Chrétien, Isaac Solomon, Leila Chimelli, and Leroy R. Sharer


• Chapter 6: Human Prion Diseases


• Markus Glatzel and Stéphane Haik


• Chapter 7: Multiple Sclerosis and Related Inflammatory Demyelinating Diseases


• Hans Lassman and Danielle Seilhean


• Chapter 8: Pathology of Degenerative Diseases of the Nervous System


• Yuichi Riku, Susana Boluda, Mel B. Feany, and Toshiki Uchihara


• Chapter 9: Acquired Metabolic Disorders


• Michael Punsoni, Luciano Neder, Isabelle Plu, and Douglas Anthony


• Chapter 10: Hereditary Metabolic Disease


• Douglas C. Anthony, Yann Nadjar, and Hans H. Goebel


• Chapter 11: Congenital Malformations and Perinatal Diseases


• Homa Adle-Biassette, Brian Harding, and Jeffrey A. Golden


• Chapter 12: Pathology of Skeletal Muscle


• Teresinha Evangelista, Anthony A. Amato, Basil T. Darras, and Umberto De Girolami


• Chapter 13: Pathology of Peripheral Neuropathy


• Jean-Michel Vallat, Douglas C. Anthony, Anthony Amato, and Umberto De Girolami


• Chapter 14: Diseases of the Pituitary Gland


• Sandro Santagata, David Meredith, Chiara Villa, and Vânia Nosé


• Appendix: Brief Survey of Neuropathology Techniques


• David Meredith and Franck Bielle