JOHN S. DUNCAN is Professor of Neurology at UCL Queen Square Institute of Neurology and Consultant Neurologist at the National Hospital for Neurology and Neurosurgery. He serves as Governor of UCLH NHS Foundation Trust and Chair of the Scientific Advisory Committee for the Epilepsy Research Institute. Previously, he was Chair of ILAE Neuroimaging and Diagnostic Methods Committees, Medical Director of Epilepsy Society, Clinical Director of Queen Square Division of UCL Hospitals, Head of Department of Epilepsy at the Institute of Neurology, and President of the British branch of ILAE.

LEY SANDER is Professor of Neurology at UCL Queen Square Institute of Neurology, Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, and Professor of Neurology at West China School of Medicine, Sichuan University, Chengdu, China. He is a Trustee of SUDEP Action and serves on the Editorial Board of The Lancet Neurology. Previously, he was Head of Department of Epilepsy at the Institute of Neurology, Member of the Management Committee of the International League Against Epilepsy, Member of the Executive Committee of the International Bureau for Epilepsy, Medical Director of Epilepsy Society, Director for Research & Development at Stichting Epilepsie Instellingen Nederland (SEIN), and Director of the WHO Centre for Research & Training in Neurosciences.

About the Editors vii

List of Contributors ix

Forewords xi

Preface xiv

Acknowledgements xvi

1 What Is Epilepsy? 1

2 Epidemiology and Natural History 6

3 The Spectrum of Seizures and Epilepsies 14

4 Risk Factors for Epilepsy 31

5 Genetics of Epilepsy 43

6 Neuroscience of Epilepsy 50

7 Neurophysiology 60

8 Neuroimaging 77

9 The Role of Neuropsychology in the Management of People with Epilepsy 95

10 First Seizure Clinic, Differential Diagnosis 104

11 Medical Treatment 112

12 Dietary, Psychological and Complementary Therapies 147

13 Epilepsy in the Acute Medical Unit 151

14 Status Epilepticus 159

15 Epilepsy Surgery 167

16 Epilepsy and Reproduction 183

17 Epilepsy in Later Life 193

18 Sleep and Epilepsy 199

19 Epilepsy, Driving, and the Law 206

20 Climate Change and Epilepsy 215

21 Premature Mortality and Sudden Unexpected Death in Epilepsy 219

22 Epilepsy and Neurodegeneration 225

23 Neuropsychiatric Aspects of Epilepsy 235

24 Functional Dissociative Seizures 241

25 Big Data and Artificial Intelligence 252

26 Future Perspectives for Epilepsy 266

Index 274