Edward H Kerns: Drug-Like Properties | Buch

Um unseren Shop nutzen zu können, müssen Sie Javascript in Ihrem Browser aktivieren.

Cover: 9780128010761 | Drug-Like Properties | Edward H Kerns (u. a.) | Buch | Gebunden | 2016

Dekorationsartikel gehören nicht zum Leistungsumfang.

Sprache: Englisch

179,95 €*

inkl. MwSt.

Versandkostenfrei per Post / DHL

Lieferzeit 1-2 Wochen

Sie können kein Produkt in den Warenkorb legen, da Javascript und technisch notwendige Cookies aktiviert sein müssen.

Kategorien:

Der Artikel ist nicht in deutscher Sprache verfasst.
Die Sprache der Produktbeschreibung und Details kann in Englisch angegeben sein. Sollten Sie Verständnisprobleme haben, wenden Sie sich gerne an uns.

Beschreibung

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. . Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

Über den Autor

Li Di is an Associate Research Fellow at Pfizer, USA

Inhaltsverzeichnis

1. Introduction2. Benefits of Property Assessment and Good Drug-Like Properties3. In Vivo Environments Affect Drug Exposure4. Prediction Rules for Rapid Property Profiling from Structure5. Lipophilicity6. pKa7. Solubility8. Permeability9. Transporters10. Blood-Brain Barrier11. Metabolic Stability12. Plasma Stability13. Solution Stability14. Plasma and Tissue Binding15. Cytochrome P450 Inhibition16. hERG Blocking17. Toxicity18. Integrity and Purity19. Pharmacokinetics20. Lead Properties21. Strategies for Integrating Drug-Like Properties into Drug Discovery22. Methods for Profiling Drug-Like Properties: General Concepts23. Lipophilicity Methods24. pKa Methods25. Solubility Methods26. Permeability Methods27. Transporter Methods28. Blood-Brain Barrier Methods29. Metabolic Stability Methods30. Plasma Stability Methods31. Solution Stability Methods32. CYP Inhibition Methods33. Plasma and Tissue Binding Methods34. hERG Methods35. Toxicity Methods36. Integrity and Purity Methods37. Pharmacokinetic Methods38. Diagnosing and Improving Pharmacokinetic Performance39. Prodrugs40. Effects of Properties on Biological Assays41. Formulation

Erscheinungsjahr:	2016
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Seiten:	580
ISBN-13:	9780128010761
ISBN-10:	0128010762
Sprache:	Englisch
Einband:	Gebunden
Autor:	Kerns, Edward H Di, Li
Besonderheit:	Unsere Aufsteiger
Hersteller:	Elsevier Science Publishing Co Inc
Maße:	283 x 225 x 35 mm
Von/Mit:	Edward H Kerns (u. a.)
Erscheinungsdatum:	25.02.2016
Gewicht:	1,777 kg

Ähnliche Produkte