Dose-Finding Designs for Early-Phase Cance...

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Beschreibung

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This bookalso covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.

Über den Autor

Takashi Daimon, Department of Biostatistics, Hyogo College of Medicine

Akihiro Hirakawa, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine

Shigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine

Zusammenfassung

Serves as an excellent resource in the design and analysis of early phase dose-finding trials

Covers a wide range of various methods for designing early phase dose-finding clinical trials in oncology and other areas

Provides an overview of complex designs for researchers in biostatistics and statistical science

Inhaltsverzeichnis

1. Introduction.- 2. Dose Finding in Early Phase Clinical Trials.- 3. Rule.- Based Designs.- 4. Continual Reassessment Method Designs.- 5. Escalation with Overdose Control Designs.- 6. Decision.- Theoretic Designs.- 7. Complex Designs.

Details

Erscheinungsjahr:	2019
Fachbereich:	Allgemeine Lexika
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Seiten:	152
Reihe:	JSS Research Series in Statistics
Inhalt:	xv 133 S. 4 s/w Illustr. 3 farbige Illustr. 133 p. 7 illus. 3 illus. in color.
ISBN-13:	9784431555841
ISBN-10:	4431555846
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Autor:	Daimon, Takashi Matsui, Shigeyuki Hirakawa, Akihiro
Auflage:	1st ed. 2019
Hersteller:	Springer Japan Springer Tokyo JSS Research Series in Statistics
Maße:	235 x 155 x 9 mm
Von/Mit:	Takashi Daimon (u. a.)
Erscheinungsdatum:	31.05.2019
Gewicht:	0,242 kg

preigu-id: 111055701