Enzo Bonora is Full Professorand Director of the Endocrinology and Metabolism Diseases Section in the School of Medicine and Surgery, Verona University, Verona, Italy. He is current president of the Italian Society of Diabetes (2014-6). Professor Bonora's clinical activity has covered the entire spectrum of endocrine and metabolic disease, both acute and chronic, and his areas of scientific research include insulin secretion and metabolism in normal subjects and various disease states, the treatment of diabetes mellitus, and the epidemiology and risk factors for type 2 diabetes and its chronic complications. He is the author of more than 220 articles in international peer-reviewed journals.

Ralph A. DeFronzo is Professor at the UT Health Science Center, San Antonio, Texas, USA, where he is Director of the Diabetes Research Unit. He is also Deputy Director of the Texas Diabetes Institute, San Antonio. His major interests focus on the pathogenesis and treatment of type 2 diabetes mellitus, the central role of insulin resistance in the metabolic-cardiovascular cluster of disorders known collectively as the Insulin Resistance Syndrome, and the etiology and treatment of diabetic nephropathy. He is the author of 55 articles in international peer-reviewed journals, as well as a variety of other publications.

Detailed and up-to-date guidelines for the prevention and treatment of diabetes

Everything on epidemiology, etiology, pathogenesis and pathophysiology

Combines a focus on clinical sciences with the discussion of basic research

Includes supplementary material: [...]

Overview of glucose homeostasis.- Insulin signaling and biological effects.- Diagnostic criteria and classification.- Epidemiology and risk factors of type 1 diabetes.- Epidemiology and risk factors of type 2 diabetes.- Genetics.- Pathogenesis of type 1 diabetes.- Pathogenesis of type 2 diabetes.- Monogenic diabetes.- Methods to assess in vivo insulin secretion and insulin sensitivity.- Diabetes screening and prediabetes.- Metabolic follow-up and home blood glucose monitoring.- Glycemic targets and prevention of chronic complications.- Prevention of type 1 diabetes.- Prevention of type 2 diabetes.- Patient education and empowerment.- Prevention of type 1 diabetes.- Prevention of type 2 diabetes.- Patient education and empowerment.- Treatment of diabetes with life style changes.- Treatment with oral drugs.- Treatment with GLP-1 receptor agonists.- Insulin treatment.- Insulin pumps.- Islet cell or pancreas transplantation.- Metabolic surgery.