Developmental Origins of Health and Diseas...

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Sprache: Englisch

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Beschreibung

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

Über den Autor

Takeo Kubota

Faculty of Child Studies, Seitoku University, Chiba, Japan

Hideoki Fukuoka

Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Zusammenfassung

Covers numerous diseases associated with DOHaD

Presents an update of our understanding of molecular mechanisms for DOHaD

Based on the latest biological data

Suggests importance of early interventions for adult diseases

Inhaltsverzeichnis

Part 1 Biological Basis.- One carbon metabolism and lipid metabolism in DOHaD.- Novel models of epigenetic gene regulation in the nutritional environment.- Epigenetic switching and neonatal nutritional environment.- Part 2 Disease and environment.- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD).- Fetal origins of hypertension.- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory.- Part 3 Transgenerational mechanism and its consequences.- Placental development and nutritional environment.- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm.- Part 4 Clinical Significance.- Preemptive epigenetic medicine based on fetal programming.

Details

Erscheinungsjahr:	2018
Fachbereich:	Therapie
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	vii 95 S. 7 s/w Illustr. 16 farbige Illustr. 95 p. 23 illus. 16 illus. in color.
ISBN-13:	9789811055256
ISBN-10:	9811055254
Sprache:	Englisch
Herstellernummer:	978-981-10-5525-6
Einband:	Gebunden
Redaktion:	Fukuoka, Hideoki Kubota, Takeo
Herausgeber:	Takeo Kubota/Hideoki Fukuoka
Auflage:	1st edition 2018
Hersteller:	Springer Singapore Springer Nature Singapore
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	260 x 183 x 12 mm
Von/Mit:	Hideoki Fukuoka (u. a.)
Erscheinungsdatum:	12.07.2018
Gewicht:	0,433 kg

Artikel-ID: 111089904