The Aim of the present research study was to explore the possibility of employing hydrotropy techniques in the formulation and evaluation of aqueous oral liquid formulation of a poorly water soluble drug Atovaquone. In the present study practically insoluble drug Atovaquone was tried to solubilize by employing the combination of physiologically compatible hydrotrope and solubilizer agents i.e. solubilizer to attempt its oral liquid formulations. Hydrotropy is a solubilisation process whereby addition of a large amount of second solute results in an increase in the aqueous solubility of another solute. Hydrotropy method help to improve aqueous solubility of Atovaquone drug having very low aq. Solubility i.e.0.2µg/ml. In this method Atovaquone was solubilized up to 4680.95 mg/ml (increase in [...] there is no liquid formulation of Atovaquone available in the market. Atovaquone syrup is useful for the pediatric as well as geriatric to improve patient compliance.