Kyle R. Eberlin, MD, Division of Plastic and Reconstructive Surgery, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

Ivica Ducic, MD, PhD, Washington Nerve Institute, McLean, VA, USA

Amy Moore, MD, Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Paul S. Cederna, MD, Section of Plastic Surgery, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

Ian Valerio, MD, Division of Plastic and Reconstructive Surgery, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

Gregory A. Dumanian, MD, Division of Plastic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Definition, Etiology, and Epidemiology of Symptomatic Neuroma.- Peripheral Sensitization: Peripheral Mechanisms of Neuroma and Neuropathic Pain.- Central Sensitization: Central Mechanisms of Neuroma and Neuropathic Pain.- Clinical Diagnosis of Symptomatic Neuroma.- The Role of Diagnostic Nerve Blocks in the Diagnosis of Neuroma.- Radiologic Imaging of Neuroma.- Neuroma Pathology: The Role of Histologic Analysis.- Pharmacotherapy and Medical Management for Neuroma and Neuropathic Pain.- Physical/Occupational Therapy and Desensitization Techniques for Neuroma.- Interventional Pain Management for Neuromas: Non-Surgical Ablative Techniques.- Neuromodulation for Painful Neuromas.- Psychosocial Aspects of Neuroma Management.- Interdisciplinary Surgical Decision Making for Painful Neuroma.- Neuroma-in-Continuity - Preoperative and Intraoperative Assessment.- Surgical Treatment of Neuroma-in-Continuity.- Intramuscular, Intra-osseous, and Intravenous Implantation of Nerve in Treatment of Painful Peripheral Neuroma.- Targeted Muscle Reinnervation for Treatment of Symptomatic Neuroma.- Regenerative Peripheral Nerve Interfaces for Treatment of Symptomatic Neuroma.- Other Surgical Techniques for Treatment of Neuroma: Relocation Nerve Grafting, Centro-central Neurorrhaphy, Nerve Cap, End-to-side neurorrhaphy.- Head and Neck Neuroma Cases.- Upper Extremity Neuroma Cases.- Upper Extremity Amputee Neuroma Cases.- Trunk Neuroma Cases: Thorax, Groin, and Pelvis.- Lower Extremity Neuroma Cases.- Lower Extremity Amputee Neuroma Cases.- Scientific Pursuit of Neuroma Management.- Future Directions in Neuroma Management.