Computational Biology of Non-Coding RNA

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Beschreibung

This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Computational Biology of Non-Coding RNA: Methods and Protocols aims to provide a state-of-the-art collection of computational methodsand approaches that will be of value to researchers interested in ncRNA field.

Zusammenfassung

Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts

Inhaltsverzeichnis

ncRNAs in Inflammatory and Infectious Diseases.- p73-Governed miRNA Networks: Translating Bioinformatics Approaches to Therapeutic Solutions for Cancer Metastasis.- Methods for Annotation and Validation of Circular RNAs from RNAseq Data.- Methods to Study Long Non-coding RNA Expression and Dynamics in Zebrafish using RNA Sequencing.- Workflow Development for the Functional Characterization of ncRNAs.- ncRNA Editing: Functional Characterization and Computational Resources.- Computational Prediction of Functional microRNA - mRNA Interactions.- Tools for Understanding miRNA-mRNA Interactions for Reproducible RNA Analysis.- Computational Resources for Prediction and Analysis of Functional miRNA and their Targetome.- Non-coding RNAs Databases: Current Status and Trends.- Controllability Methods for Identifying Associations between Critical Control ncRNAs and Human Diseases.- Network-based Methods and Other Approaches for Predicting lncRNA Functions and Disease Associations.- Integration ofmiRNA and mRNA Expression Data for Understanding Etiology of Gynecologic Cancers.- Quantitative Characteristic of ncRNA Regulation in Gene Regulatory Networks.- Kinetic Modeling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs.- Modeling ncRNA-mediated Circuits in Cell Fate Decision.- Modeling Long ncRNA-mediated Regulation in the Mammalian Cell Cycle.

Details

Erscheinungsjahr:	2019
Fachbereich:	Allgemeines
Genre:	Biologie , Importe
Rubrik:	Naturwissenschaften & Technik
Medium:	Buch
Inhalt:	xii 451 S. 13 s/w Illustr. 65 farbige Illustr. 451 p. 78 illus. 65 illus. in color.
ISBN-13:	9781493989812
ISBN-10:	1493989812
Sprache:	Englisch
Herstellernummer:	978-1-4939-8981-2
Einband:	Gebunden
Redaktion:	Lai, Xin Vera, Julio Gupta, Shailendra K.
Herausgeber:	Xin Lai/Shailendra K Gupta/Julio Vera
Auflage:	1st edition 2019
Hersteller:	Springer US Springer New York
Verantwortliche Person für die EU:	Humana Press in Springer Science + Business Media, Heidelberger Platz 3, D-14197 Berlin, juergen.hartmann@springer.com
Maße:	260 x 183 x 31 mm
Von/Mit:	Xin Lai (u. a.)
Erscheinungsdatum:	12.01.2019
Gewicht:	1,063 kg