Calcitonin Gene-Related Peptide (CGRP) Mec...

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Beschreibung

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Zusammenfassung

This book provides a thorough review of the key recent research into the role of CGRP in health and disease.

In particular, it enables and enriches understanding of CGRP in migraine pathophysiology.

Provides a full update of the latest therapeutic perspectives and clinical advancements with potential therapeutic agents that block the actions of CGRP.

Inhaltsverzeichnis

1. CGRP Discovery and Timeline.- 2. CGRP Receptor Biology: Is There More Than One Receptor?.- 3. The Structure of the CGRP and Related Receptors.- 4. CGRP Receptor Signalling Pathways.- 5. Pathways of CGRP Release from Primary Sensory Neurons.- 6. CGRP in Animal Models of Migraine.- 7. CGRP in Human Models of Migraine.- 8. Role of CGRP in Migraine.- 9. Understanding CGRP and Cardiovascular Risk.- 10. CGRP and Painful Pathologies other than Headache.- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.

Details

Erscheinungsjahr:	2019
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Reihe:	Handbook of Experimental Pharmacology
Inhalt:	vii 192 S. 6 s/w Illustr. 17 farbige Illustr. 192 p. 23 illus. 17 illus. in color.
ISBN-13:	9783030214531
ISBN-10:	3030214532
Sprache:	Englisch
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Geppetti, Pierangelo Brain, Susan D.
Herausgeber:	Susan D Brain/Pierangelo Geppetti
Auflage:	1st ed. 2019
Hersteller:	Springer International Publishing Handbook of Experimental Pharmacology
Maße:	241 x 160 x 17 mm
Von/Mit:	Pierangelo Geppetti (u. a.)
Erscheinungsdatum:	11.09.2019
Gewicht:	0,471 kg