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Cover: 9783639653465 | Arbidol: an antiviral against globally prevalent viruses | Taschenbuch
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Arbidol: an antiviral against globally prevalent viruses
A promising antiviral strategy
Taschenbuch von Eve-Isabelle Pécheur (u. a.)
Sprache: Englisch

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Beschreibung
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
Über den Autor
Eve-Isabelle Pécheur (Pharm.D. - Ph.D.) is group leader CNRS at the Cancer Research Center of Lyon, France. Her main research interests are the role of the liver microenvironment in hepatitis B and C pathogenesis, and the discovery of novel antiviral strategies. She is the author of 60 publications.
Details
Erscheinungsjahr: 2017
Fachbereich: Allgemeines
Genre: Biologie
Rubrik: Naturwissenschaften & Technik
Thema: Lexika
Medium: Taschenbuch
Inhalt: 116 S.
ISBN-13: 9783639653465
ISBN-10: 3639653467
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Pécheur, Eve-Isabelle
Polyak, Stephen J.
Hersteller: Éditions universitaires européennes
Maße: 220 x 150 x 8 mm
Von/Mit: Eve-Isabelle Pécheur (u. a.)
Erscheinungsdatum: 06.02.2017
Gewicht: 0,191 kg
Artikel-ID: 108499659
Über den Autor
Eve-Isabelle Pécheur (Pharm.D. - Ph.D.) is group leader CNRS at the Cancer Research Center of Lyon, France. Her main research interests are the role of the liver microenvironment in hepatitis B and C pathogenesis, and the discovery of novel antiviral strategies. She is the author of 60 publications.
Details
Erscheinungsjahr: 2017
Fachbereich: Allgemeines
Genre: Biologie
Rubrik: Naturwissenschaften & Technik
Thema: Lexika
Medium: Taschenbuch
Inhalt: 116 S.
ISBN-13: 9783639653465
ISBN-10: 3639653467
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Pécheur, Eve-Isabelle
Polyak, Stephen J.
Hersteller: Éditions universitaires européennes
Maße: 220 x 150 x 8 mm
Von/Mit: Eve-Isabelle Pécheur (u. a.)
Erscheinungsdatum: 06.02.2017
Gewicht: 0,191 kg
Artikel-ID: 108499659
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