Laurens Holmes, Jr. is a specialist in Immunology and Infectious Disease as well as an expert in cancer epidemiology and biostatistical modeling. He is a major proponent of aberrant epigenomic modulations in disease incidence, morbidity, prognosis, mortality and survival; and a former Head of the Epidemiology Laboratory at the Nemours Center for Childhood Cancer Research, Wilmington; former clinical and translational science education and training director, Medical College of Wisconsin, Milwaukee; as well as a former Professor of Molecular Epidemiology and Clinical Trials at the University of Delaware, USA. Professor Holmes is currently the Director of the Graduate Public Health Program at Delaware State University, Dover, USA.

Part 1: Epidemiology and Epigenomic Epidemiology Contribution in Clinical Medicine and Public Health. 1.Introductory Epigenomic Epidemiology: Basic Concepts and Application. 2.Public Health, Epidemiology and Translational Epigenomic Epidemiology Perspective. 3.Scientific Research Concept and Application: Public Health, Clinical Medicine and Epigenomic Epidemiology Studies. 4.Disease Ascertainment-Diagnostic and Screening Test. 5.Epigenomic Epidemiology: Disease Association, Etiology, Prognosis and Outcomes. Part 2 Traditional and Modern Epidemiologic Designs 6.Measures of Disease Occurrence and Effect or Association. 7.Ecologic Design. 8.Cross-Sectional Study Design (Non-experimental). 9.Case-Control (Comparison/Non-Case) Design. 10.Cohort Designs: Prospective, Retrospective, Ambi-directional. 11.Human Experimental Design-Clinical Trials. 12.Epidemiologic Causal Inference: Causality Web, Meta-Analysis, Quantitative Evidence Synthesis (QES). Part 3 Laboratory Techniques and Epigenomic Mechanistic Process in Epidemiologic Principles, Concept and Application. 13.Epigenomic Laboratory Procedures: Mechanistic Process and Techniques. 14.Epigenomic Studies Perspective: Malignant Neoplasm, Protastic Adenocarcinoma-Prostate Cancer CaP. 15.Pediatric Acute Lymphoblastic Leukemia (ALL): Aberrant Epigenomic Modulation Surrogate. 16.Cardiovascular Disease (CVD) : DNA Methylation of Candidate Genes (ACE II, IFN-¿, AGTR1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension.