Radclyffe has written over fifty romance and romantic intrigue novels, dozens of short stories, and, writing as L.L. Raand, has authored a paranormal romance series, The Midnight Hunters.

She is an eight-time Lambda Literary Award finalist in romance, mystery, and erotica-winning in both romance (Distant Shores, Silent Thunder) and erotica (Erotic Interludes 2: Stolen Moments edited with Stacia Seaman and In Deep Waters 2: Cruising the Strip written with Karin Kallmaker). A member of the Saints and Sinners Literary Hall of Fame, she is also an RWA/FF&P Prism Award winner for Secrets in the Stone, an RWA FTHRW Lories and RWA HODRW winner for Firestorm, an RWA Bean Pot winner for Crossroads, and an RWA Laurel Wreath winner for Blood Hunt. In 2014 she was awarded the Dr. James Duggins Outstanding Mid-Career Novelist Award by the Lambda Literary Foundation. She is a featured author in the 2015 documentary film Love Between the Covers from Blueberry Hill Productions.

She is also the president of Bold Strokes Books, one of the world's largest independent LGBTQ publishing companies.