The Science and Business of Drug Discovery

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Beschreibung

The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices.
The following topics are covered:Different types of drugs: from small molecules to stem cells
Background to chemistry of small and large molecules
Historical background to drug discovery, pharmacology and biotechnology
The drug discovery pipeline: from target discovery to marketed medicine
Commercial aspects of drug discovery
Challenges to the biopharmaceutical industry and its responses
Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators

Über den Autor

Dr. Edward D. Zanders has over 30 years' experience as a scientist and research manager in both a major pharmaceutical company and in smaller biotechnology organizations. He has been responsible for a number of drug discovery programs for diseases such as asthma and rheumatoid arthritis and has been involved in research management at a senior level. He has also published extensively on subjects ranging from biochemistry and immunology to computer-aided drug design and the application of online networking to drug discovery. More recently he has written about drug targets in the human genome and a survey of drug discovery for glioblastoma. In 2004 he founded PharmaGuide Ltd, a training and consultancy company that delivers courses on the drug discovery industry to various professional groups including technology transfer executives, recruiters and technical translators. It is through delivering these courses that he has been able to develop his own way of conveying complex information about drug discovery to non scientists, while at the same time being able to communicate with PhD level scientists at their level of expertise.

Zusammenfassung

Written for those in drug development who want an overview

Filled with illustrations figures and case histories

Total coverage of drug discovery pipeline

Addresses the commercial aspects as well as the challenges

Inhaltsverzeichnis

Introduction.- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry.- Introduction to Drugs and Drug Targets.- Background to chemistry of small and large molecules.- Laying the foundations- Drug discovery from antiquity to the twenty first century.- Part II-The drug development pipeline - discovery to testing in humans.- Drug discovery pipeline overview.- Target discovery.- Medicinal chemistry.- Biotherapeutics.- Screening for hits.- Process chemistry and formulation.- Preclinical development.- Part III-The drug development pipeline - clinical trials to marketing authorisation.- Clinical trials.- Regulatory affairs and marketing approval.- Diagnostics and personalized medicine.- Putting it All Together: a drug development case history.- Part IV- The Global Pharmaceuticals Business.- Commercial aspects of drug development.- Challenges and responses.- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives.- Recruitment Executives.- Pharmaceutical translators and Interpreters.

Details

Erscheinungsjahr:	2021
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Seiten:	420
Inhalt:	xvii 402 S. 82 s/w Illustr. 20 farbige Illustr. 402 p. 102 illus. 20 illus. in color.
ISBN-13:	9783030578169
ISBN-10:	303057816X
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Autor:	Zanders, Edward D.
Auflage:	2nd ed. 2020
Hersteller:	Springer International Publishing Springer International Publishing AG
Maße:	235 x 155 x 23 mm
Von/Mit:	Edward D. Zanders
Erscheinungsdatum:	11.11.2021
Gewicht:	0,633 kg

preigu-id: 120702782