Domenico Ribatti: The Mast Cell | Taschenbuch

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Cover: 9783030241926 | The Mast Cell | A Multifunctional Effector Cell | Domenico Ribatti

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Sprache: Englisch

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Beschreibung

Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in thecontext of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.

Über den Autor

The author, Domenico Ribatti, Full professor of the University of Bari, is an expert in the field of Mast Cells with more than 800 publications.

Zusammenfassung

This book contains a comprehensive and updated view of Mast Cell Biology

Broadens the understanding of Mast Cells from their classic immunological role to include their role in human health homeostasis, disease response and tissue regeneration

This highly informative book is particularly relevant to students and academics interested in cancer, neurodegeneration, angiogenesis, inflammation and related fields

Inhaltsverzeichnis

Foreword.- Mast cell ontogeny.- Staining of mast cells.- Mast cells heterogeneity.- Mast cell biology and functions.- Mast cells in arteriogenesis.- Mast cells in primary systemic vasculitides.- Mast cells in blood-brain barrier alterations and neurodegenerative diseases.- Mast cells and basophils: a link between angiogenesis and inflammation in allergic diseases.- Mast cells in tumor fate.- Mast cells in tumor angiogenesis and lymphoangiogenesis.- Mast cells as therapeutic target in cancer.- Index.

Details

Erscheinungsjahr:	2020
Fachbereich:	Therapie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Seiten:	120
Inhalt:	vii 112 S. 4 s/w Illustr. 8 farbige Illustr. 112 p. 12 illus. 8 illus. in color.
ISBN-13:	9783030241926
ISBN-10:	3030241920
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Autor:	Ribatti, Domenico
Auflage:	1st ed. 2019
Hersteller:	Springer International Publishing
Maße:	235 x 155 x 7 mm
Von/Mit:	Domenico Ribatti
Erscheinungsdatum:	15.08.2020
Gewicht:	0,221 kg

preigu-id: 118817254