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Acknowledgments xiii
I Introduction and Background
1 The Basal Ganglia: Why and Where? 3
2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15
3 The Synaptic Connections of the Basal Ganglia Network 27
4 Computational Modeling of Brain and Behavior 39
5 Principles of Neurophysiological Data Acquisition 43
6 Principles of Neurophysiological Analysis 61
II Computational Physiology of the Healthy Basal Ganglia
7 Physiology of the Basal Ganglia 77
8 Basal Ganglia Physiology: The Roads Less Traveled 89
9 Box-and-Arrow Rate Models of the Basal Ganglia 105
10 Reinforcement-Learning Actor/Critic Models of the Basal Ganglia 117
11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133
12 The Basal Ganglia as one of many State-to-Action Loops 145
III Computational Physiology of Basal Ganglia Disorders and their Therapy
13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163
14 Animal Models of Parkinson's Disease 171
15 Physiology of Parkinson's Disease: Animal Models 179
16 Physiology of Parkinson's Disease: Human 195
17 Pharmacotherapy of Parkinson's Disease 203
18 Deep Brain Stimulation Therapy for Parkinson's Disease 215
19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225
IV From the Basal Ganglia and Brain to the Mind
20 The Basal Ganglia, Free Will, and Human Responsibility 241
Notes 247
References 261
Index 295
| Erscheinungsjahr: | 2021 |
|---|---|
| Genre: | Biologie |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Taschenbuch |
| Seiten: | 288 |
| Inhalt: | Einband - flex.(Paperback) |
| ISBN-13: | 9780262543118 |
| ISBN-10: | 0262543117 |
| Sprache: | Englisch |
| Einband: | Kartoniert / Broschiert |
| Autor: | Bergman, Hagai |
| Hersteller: | MIT Press Ltd |
| Maße: | 254 x 176 x 19 mm |
| Von/Mit: | Hagai Bergman |
| Erscheinungsdatum: | 12.10.2021 |
| Gewicht: | 0,666 kg |
Acknowledgments xiii
I Introduction and Background
1 The Basal Ganglia: Why and Where? 3
2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15
3 The Synaptic Connections of the Basal Ganglia Network 27
4 Computational Modeling of Brain and Behavior 39
5 Principles of Neurophysiological Data Acquisition 43
6 Principles of Neurophysiological Analysis 61
II Computational Physiology of the Healthy Basal Ganglia
7 Physiology of the Basal Ganglia 77
8 Basal Ganglia Physiology: The Roads Less Traveled 89
9 Box-and-Arrow Rate Models of the Basal Ganglia 105
10 Reinforcement-Learning Actor/Critic Models of the Basal Ganglia 117
11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133
12 The Basal Ganglia as one of many State-to-Action Loops 145
III Computational Physiology of Basal Ganglia Disorders and their Therapy
13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163
14 Animal Models of Parkinson's Disease 171
15 Physiology of Parkinson's Disease: Animal Models 179
16 Physiology of Parkinson's Disease: Human 195
17 Pharmacotherapy of Parkinson's Disease 203
18 Deep Brain Stimulation Therapy for Parkinson's Disease 215
19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225
IV From the Basal Ganglia and Brain to the Mind
20 The Basal Ganglia, Free Will, and Human Responsibility 241
Notes 247
References 261
Index 295
| Erscheinungsjahr: | 2021 |
|---|---|
| Genre: | Biologie |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Taschenbuch |
| Seiten: | 288 |
| Inhalt: | Einband - flex.(Paperback) |
| ISBN-13: | 9780262543118 |
| ISBN-10: | 0262543117 |
| Sprache: | Englisch |
| Einband: | Kartoniert / Broschiert |
| Autor: | Bergman, Hagai |
| Hersteller: | MIT Press Ltd |
| Maße: | 254 x 176 x 19 mm |
| Von/Mit: | Hagai Bergman |
| Erscheinungsdatum: | 12.10.2021 |
| Gewicht: | 0,666 kg |
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