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Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylatenucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.
This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylatenucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.
This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Prof. Dr. hab. Stefan Jurga,
Adam Mickiewicz University, Nanobiomedical Center,
Poznä, Poland
[...]
Prof. Dr.hab Jan Barciszewski,
Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznä, Poland and
Adam Mickiewicz University, Nanobiomedical Center, Poznä, Poland
[...]
Comprehensively reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases
Highlights clinical applications of epigenetic editing in cancer treatment and aging
Highlights hot topics such as cellular plasticity, novel biomarkers and genome-wide association studies
Erscheinungsjahr: | 2019 |
---|---|
Fachbereich: | Andere Fachgebiete |
Genre: | Medizin |
Rubrik: | Wissenschaften |
Medium: | Buch |
Seiten: | 636 |
Reihe: | RNA Technologies |
Inhalt: |
xi
624 S. 21 s/w Illustr. 57 farbige Illustr. 624 p. 78 illus. 57 illus. in color. |
ISBN-13: | 9783030147914 |
ISBN-10: | 3030147916 |
Sprache: | Englisch |
Herstellernummer: | 978-3-030-14791-4 |
Ausstattung / Beilage: | HC runder Rücken kaschiert |
Einband: | Gebunden |
Redaktion: |
Barciszewski, Jan
Jurga, Stefan |
Herausgeber: | Stefan Jurga/Jan Barciszewski |
Auflage: | 1st ed. 2019 |
Hersteller: |
Springer International Publishing
RNA Technologies |
Maße: | 241 x 160 x 40 mm |
Von/Mit: | Jan Barciszewski (u. a.) |
Erscheinungsdatum: | 11.09.2019 |
Gewicht: | 1,109 kg |
Prof. Dr. hab. Stefan Jurga,
Adam Mickiewicz University, Nanobiomedical Center,
Poznä, Poland
[...]
Prof. Dr.hab Jan Barciszewski,
Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznä, Poland and
Adam Mickiewicz University, Nanobiomedical Center, Poznä, Poland
[...]
Comprehensively reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases
Highlights clinical applications of epigenetic editing in cancer treatment and aging
Highlights hot topics such as cellular plasticity, novel biomarkers and genome-wide association studies
Erscheinungsjahr: | 2019 |
---|---|
Fachbereich: | Andere Fachgebiete |
Genre: | Medizin |
Rubrik: | Wissenschaften |
Medium: | Buch |
Seiten: | 636 |
Reihe: | RNA Technologies |
Inhalt: |
xi
624 S. 21 s/w Illustr. 57 farbige Illustr. 624 p. 78 illus. 57 illus. in color. |
ISBN-13: | 9783030147914 |
ISBN-10: | 3030147916 |
Sprache: | Englisch |
Herstellernummer: | 978-3-030-14791-4 |
Ausstattung / Beilage: | HC runder Rücken kaschiert |
Einband: | Gebunden |
Redaktion: |
Barciszewski, Jan
Jurga, Stefan |
Herausgeber: | Stefan Jurga/Jan Barciszewski |
Auflage: | 1st ed. 2019 |
Hersteller: |
Springer International Publishing
RNA Technologies |
Maße: | 241 x 160 x 40 mm |
Von/Mit: | Jan Barciszewski (u. a.) |
Erscheinungsdatum: | 11.09.2019 |
Gewicht: | 1,109 kg |