Michael Sheetz: The Cell as A Machine | Buch

Cover: 9781107052734 | The Cell as A Machine | Hanry Yu | Buch | HC gerader Rücken kaschiert

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Sprache: Englisch

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Beschreibung

A systematic and mathematically accessible introductory text explaining cell functions through the engineering principles of robust devices.

Über den Autor

Michael Sheetz is Chair of Biological Science at Columbia University, Founding Chair of the Department of Cell Biology at Duke University, and Founding Director of the Mechanobiology Institute at the National University of Singapore. He is also a recipient of the Albert Lasker Basic Medical Research Award.

Inhaltsverzeichnis

Part I. Principle of Complex Function in Robust Machines: 1. Robust self-replicating machines shaped by evolution; 2. Complex functions of robust machines with emergent properties; 3. Integrated complex functions with dynamic feedback; 4. Cells exhibit multiple states, each with different functions; 5. Life at low Reynolds number and the mesoscale leads to stochastic phenomena; Part II. Design and Operation of Complex Functions: 6. Engineering lipid bilayers to provide fluid boundaries and mechanical controls; 7. Membrane trafficking - flow and barriers create asymmetries; 8. Signaling and cell volume control through ion transport and volume regulators; 9. Structuring a cell by cytoskeletal filaments; 10. Moving and maintaining functional assemblies with motors; 11. Microenvironment controls life, death and regeneration; 12. Adjusting cell shape and forces with dynamic filament networks; 13. DNA packaging for information retrieval and propagation; 14. Transcribing the right information and packaging for delivery; 15. Turning RNA into functional proteins and removing unwanted proteins; Part III. Coordination of Complex Functions: 16. How to approach a coordinated function - cell rigidity sensing and force generation across length scale; 17. Integration of cellular functions for decision making; 18. Moving from omnipotency to death; 19. Cancer versus regeneration - the wrong versus right response to the microenvironment.

Erscheinungsjahr:	2019
Fachbereich:	Therapie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
ISBN-13:	9781107052734
ISBN-10:	1107052734
Sprache:	Englisch
Ausstattung / Beilage:	HC gerader Rücken kaschiert
Einband:	Gebunden
Autor:	Sheetz, Michael Yu, Hanry
Hersteller:	Cambridge University Press
Maße:	260 x 208 x 32 mm
Von/Mit:	Michael Sheetz (u. a.)
Erscheinungsdatum:	26.03.2019
Gewicht:	1,604 kg

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