The Blood Brain Barrier and Inflammation

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Sprache: Englisch

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Beschreibung

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Über den Autor

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.

Zusammenfassung

Provides a comprehensive overview on the role of the BBB during CNS inflammation

Covers inflammatory diseases, like autoimmune and viral induced CNS inflammation, cerebral malaria, multiple sclerosis, bacterial meningitis, and others

Presents methods to study neuro-inflammation, employing BBB animal models and imaging techniques

Inhaltsverzeichnis

General Introduction to Barrier Mechanisms in the Central Nervous System.- Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research.- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions.- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases.- Leakage at Blood-neural Barriers.- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology.- MicroRNAs in Brain Endothelium and Inflammation.- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases.- Pathways Across the Blood Brain Barrier.- Neuroinflammation in Bacterial Meningitis.- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.

Details

Erscheinungsjahr:	2018
Fachbereich:	Therapie
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Reihe:	Progress in Inflammation Research
Inhalt:	vi 286 S. 8 s/w Illustr. 24 farbige Illustr. 286 p. 32 illus. 24 illus. in color.
ISBN-13:	9783319833088
ISBN-10:	3319833081
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Lyck, Ruth Enzmann, Gaby
Herausgeber:	Ruth Lyck/Gaby Enzmann
Hersteller:	Springer Springer International Publishing AG Progress in Inflammation Research
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 15 mm
Von/Mit:	Ruth Lyck (u. a.)
Erscheinungsdatum:	21.07.2018
Gewicht:	0,5 kg