There are many important axes in human anatomy, including the Hypothalamic-Pituitary-Adrenal Axis, the Liver Triad Axis, and the Gut-Brain Axis. Less well known to Western medical scientists is a parallel system that can develop in the subtle energy body of the human being. This energy body, while not visible with our current technology, is well known in esoteric healing traditions. In The Biology of Transformation, author Tiffany Jean Barsotti proposes a new axis in human anatomy, the Reticular Activating System-Vagus Nerve-Alta Major Chakra Axis as the nexus of communication from Higher Consciousness to the physical and subtle energy bodies of the human being. Barsotti draws extensively on the existing neuroscience and human anatomy literature, as well as the teachings of esoteric traditions, including Tibetan. She offers a nonlinear journey that grapples with ancient teachings and how they relate to the body and mind as perceived by modern medicine. With the goal of creating a foundation and stimulating thought regarding energy physiology, the body-mind connection, and how our intention shapes our health and environment, The Biology of Transformation provides a scientific review of recent advances in neurophysiology that focus on awakening awareness and consciousness.