The Voice that is Missing The Evolving Role of Patients and Families in Escalation of Care.- Causes of Failure to Rescue.- Rapid Response Systems and the Culture of Safety.- Systems Thinking Standing on the Shoulders of Giants.- A Brief History of Rapid Response Systems.- Rapid Response Systems General Principles.-The Overview of the Afferent Limb.- The Overview of the Afferent Limb.-Track and Trigger System Identifying and Predicting Patient Deterioration Through Scores and Algorithms.- Continuous Vital Sign Monitoring for Early Detection of Deterioration Outside High Intensity Care Settings.- When Patients (And Families) Raise the Alarm Patient and Family Activated Escalations Systems As a Safety Strategy for Hospitals.- Impact of Delayed Rapid Response System Activation.-Overview of the Efferent Limb.- Tiered Rapid Response Systems.- MET Physician Led Rapid Response Teams.-Use of Protocols during a Rapid Response Event.- Equipment Medications and Supplies for a Rapid Response Team.- Rapid Response for Dying Patients Without Not for Resuscitation Orders.- Crisis Teams for Obstetric Patients.- Rapid Response Systems in the Emergency Department.- Second Victims Care for Caregivers Using a Rapid Response Model.- Hospital Rapid Response Systems and Disasters.- Other Efferent Limb Teams.-Measuring Complex and Macro Research in Rapid Response Systems.- Governance of the Rapid Response System.-The Resuscitation Officer Responsibilities and Impact.- Ward Staff Education in the Age of Rapid Response Systems.- Simulation Based Training for Rapid Response Systems in Medical Education, a Review.-Crisis Resource Management Training the Responders.- Measuring the Quality of Rapid Response Applying the Quadruple Aim to Patient Safety.- Rapid Response System Informatics.- Rapid assessment Critical Events (RACE) Team Medical Directives.- Emerging Research Topics in Rapid Response.-The Role, Determinants And Impact Of RRS On End-Of-Life Care Orders.- Rapid Response for Patients with End of Life Needs.- Rapid Response Systems and the Management of the End of Life.- Rapid Response Systems in Australia and New Zealand.-Rapid Response Systems in Europe.-Rapid Response Systems in Asia.-Rapid Response Systems in Central and South America.-Rapid Response System in Africa.-Pediatric Rapid Response Systems: Introduction.-Recognition of Clinical Deterioration in Children.-Intensity of Care in Pediatric Rapid Response Systems.-Pediatric Rapid Response System: Re-direction of Care.-The Rapid Response System: Building and Maintaining the System.-Parents, Patients, Ward Clinicians and other Stakeholders in the Rapid Response System.-The Approach to the Child with Hypotension. -Practical Approach to the Child with Rapid Breathing.-Approach to the Child with reduced level of consciousness.-Rapid Response Systems: Neonatal Model.- Metrics to Monitor the Function and Performance of the Pediatric Rapid Response System.-Rapid Response teams in Mass Casualty Incidents.