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This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data.
In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies.
The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.
This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data.
In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies.
The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.
Jozef Nauta is a principal statistician, with more than 25 years of experience in the pharmaceutical industry, and with special interest in the development of influenza vaccines. During his career he has published numerous journal articles on statistics and vaccines. He currently participates in Development of Robust and Innovative Vaccine Effectiveness (DRIVE), a public private partnership that advances European cooperation in influenza vaccine effectiveness studies, funded by, amongst others the Innovative Medicines Initiative (IMI). He lives with his wife and son in Amsterdam, the Netherlands.
1.The Interplay Between Microorganisms and the Immune System.- 2. Analysis of Immunogenicity Data.- 3. Vaccine Field Studies.- 4. Correlates of Protection.- 5. Analysis of Vaccine Safety Data.
| Erscheinungsjahr: | 2021 |
|---|---|
| Fachbereich: | Wahrscheinlichkeitstheorie |
| Genre: | Mathematik |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Taschenbuch |
| Seiten: | 256 |
| Reihe: | Springer Series in Pharmaceutical Statistics |
| Inhalt: |
xxii
234 S. 10 s/w Illustr. 234 p. 10 illus. |
| ISBN-13: | 9783030376956 |
| ISBN-10: | 3030376958 |
| Sprache: | Englisch |
| Ausstattung / Beilage: | Paperback |
| Einband: | Kartoniert / Broschiert |
| Autor: | Nauta, Jozef |
| Auflage: | 2nd ed. 2020 |
| Hersteller: |
Springer International Publishing
Springer International Publishing AG Springer Series in Pharmaceutical Statistics |
| Maße: | 235 x 155 x 15 mm |
| Von/Mit: | Jozef Nauta |
| Erscheinungsdatum: | 15.03.2021 |
| Gewicht: | 0,394 kg |
Jozef Nauta is a principal statistician, with more than 25 years of experience in the pharmaceutical industry, and with special interest in the development of influenza vaccines. During his career he has published numerous journal articles on statistics and vaccines. He currently participates in Development of Robust and Innovative Vaccine Effectiveness (DRIVE), a public private partnership that advances European cooperation in influenza vaccine effectiveness studies, funded by, amongst others the Innovative Medicines Initiative (IMI). He lives with his wife and son in Amsterdam, the Netherlands.
1.The Interplay Between Microorganisms and the Immune System.- 2. Analysis of Immunogenicity Data.- 3. Vaccine Field Studies.- 4. Correlates of Protection.- 5. Analysis of Vaccine Safety Data.
| Erscheinungsjahr: | 2021 |
|---|---|
| Fachbereich: | Wahrscheinlichkeitstheorie |
| Genre: | Mathematik |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Taschenbuch |
| Seiten: | 256 |
| Reihe: | Springer Series in Pharmaceutical Statistics |
| Inhalt: |
xxii
234 S. 10 s/w Illustr. 234 p. 10 illus. |
| ISBN-13: | 9783030376956 |
| ISBN-10: | 3030376958 |
| Sprache: | Englisch |
| Ausstattung / Beilage: | Paperback |
| Einband: | Kartoniert / Broschiert |
| Autor: | Nauta, Jozef |
| Auflage: | 2nd ed. 2020 |
| Hersteller: |
Springer International Publishing
Springer International Publishing AG Springer Series in Pharmaceutical Statistics |
| Maße: | 235 x 155 x 15 mm |
| Von/Mit: | Jozef Nauta |
| Erscheinungsdatum: | 15.03.2021 |
| Gewicht: | 0,394 kg |
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