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The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.
The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.
Elena Lenci received the Doctor Europaeus PhD in Chemical Science in 2017 from the University of Florence, after spending a research period at the University of Oxford, UK. She is currently a postdoctoral researcher at the Department of Chemistry, University of Florence, developing novel amino acid- and sugar-derived scaffolds for medicinal chemistry projects. In 2015 she was awarded the Reaxys - Italian Chemical Society Young Researcher Award, and in 2017 she received the International Award for Young Chemists NATCHEMDRUGS. Besides her work in organic chemistry, she has served as a board-member in the Young Group of the Italian Chemical Society since 2016, and as a board member in the Chemical Cultural Diffusion Group since 2019.
2. Chemical Reactions for Building Small Molecules
3. Chemoinformatics to Assess Chemical Diversity and Complexity of Small Molecules
4. Virtual Screening of Small Molecule Libraries
5. Biophysical Methods for Screening and Characterization of Small Molecules
6. Small Molecule Peptidomimetics: Principles, Molecules, and Applications
7. sp2-Iminosugars as Chemical Mimics for Glycodrug Design
8. Synthesis and Biological Properties of Spiroacetal-containing Small Molecules
9. Centrocountins: Synthesis and Chemical Biology of Nature Inspired Indoloquinolizines
10. PPIs as Therapeutic Targets for Anti-cancer Drug Discovery: The Case Study of MDM2 and BET Bromodomain Inhibitors
11. Discovery of Small Molecules for the Treatment of Alzheimer's Disease
| Erscheinungsjahr: | 2019 |
|---|---|
| Fachbereich: | Organische Chemie |
| Genre: | Chemie, Importe |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Taschenbuch |
| Inhalt: | Einband - flex.(Paperback) |
| ISBN-13: | 9780128183496 |
| ISBN-10: | 0128183497 |
| Sprache: | Englisch |
| Einband: | Kartoniert / Broschiert |
| Autor: |
Trabocchi, Andrea
Lenci, Elena |
| Redaktion: |
Trabocchi, Andrea
Lenci, Elena |
| Hersteller: | Elsevier Inc |
| Verantwortliche Person für die EU: | Kolibri 360 GmbH, Ettore-Bugatti-Str. 6-14, D-51149 Köln, produktsicherheit@kolibri360.de |
| Maße: | 235 x 191 x 19 mm |
| Von/Mit: | Andrea Trabocchi (u. a.) |
| Erscheinungsdatum: | 02.12.2019 |
| Gewicht: | 0,617 kg |