Sequence ¿ Evolution ¿ Function | Buch

Cover: 9781402072741 | Sequence ¿ Evolution ¿ Function | Michael Galperin (u. a.) | Buch

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Sprache: Englisch

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Beschreibung

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis.

Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Zusammenfassung

Completed and ongoing genome sequencing projects

Databases that store and organize genomic data, with their unique advantages and pitfalls

Principles and methods of genome analysis and annotation

Ways to automate the searches and increase search sensitivity while minimizing the error rate

The first lessons from the Human Genome Project

The contribution of comparative genomics to the understanding of hereditary diseases and cancer

Fundamental and practical applications of comparative genomics

Use of complete genomes for evolutionary analysis

Application of comparative genomics for identification of potential drug targets in microbial genomes

Problems for Further Study, which are designed to be solved by using methods available through the WWW

Inhaltsverzeichnis

Personal Interludes.- 1. Genomes from Phage to Human.- 2. The Evolutionary Concept in Genetics and Genomics.- 3. Information Sources for Genomics.- 4. Principles and Methods of Sequence Analysis.- 5. Genome Annotation and Analysis.- 6. Comparative Genomics and New Evolutionary Biology.- 7. Evolution of Central Metabolic Pathways: The Playground of Non-orthologous Gene Displacement.- 8. Genomes and the Protein Universe.- 9. Epilogue: Peering through the crystal ball.- Appendices.- 1. Glossary.- 2. Useful WWW sites.- Databases.- Major genome sequencing centers.- 3. Problems.- References.

Details

Erscheinungsjahr:	2002
Fachbereich:	Zoologie
Genre:	Biologie
Rubrik:	Naturwissenschaften & Technik
Medium:	Buch
Inhalt:	xiv 462 S.
ISBN-13:	9781402072741
ISBN-10:	1402072740
Sprache:	Englisch
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Autor:	Galperin, Michael Koonin, Eugene V.
Hersteller:	Springer US Springer US, New York, N.Y.
Maße:	241 x 160 x 35 mm
Von/Mit:	Michael Galperin (u. a.)
Erscheinungsdatum:	30.11.2002
Gewicht:	0,982 kg

Artikel-ID: 102386918