1. What is science-based therapy? David F. Tolin and Stephen Hupp; 2. Depressive disorders John R. McQuaid and Alfiee Breland-Noble; 3. Bipolar spectrum disorders Monica Ramirez Basco; 4. Anxiety disorders Dean McKay; 5. Obsessive-compulsive disorder Dean McKay; 6. Posttraumatic stress disorder Carmen P. McLean and Eve A. Rosenfeld; 7. Dissociative disorders Steven Jay Lynn, Fiona Sleight, Craig P. Polizzi, Damla Aksen, Lawrence Patihis, Henry Otgaar and Olivier Dodier; 8. Pain Laura Nelson Darling, Kristine Lee and John Otis; 9. Eating disorders Jamie M. Loor, Jennifer A. Battles, Brooke L. Bennett, Danae L. Hudson and Brooke L. Whisenhunt; 10. Insomnia disorder Parky Lau, Onkar Marway and Colleen Carney; 11. Sexual dysfunctions Amy D. Lykins and Marta Meana; 12. Substance use disorders Victoria E. Stead, Andrew Lumb, Jennifer Brasch and James MacKillop; 13. Cognitive loss Claudia Drossel; 14. Antisocial behavior Devon L. L. Polaschek; 15. Borderline personality and other personality disorders Joel Paris; 16. Psychosis and schizophrenia Elizabeth Thompson, Katherine Visser, Madeline Ward and Brandon A. Gaudiano; 17. Autism spectrum and intellectual disability Frank R. Cicero; 18. Attention-deficit/hyperactivity disorder Mary V. Solanto; 19. Tic disorders Kirsten Bootes, Emily Braley and Michael B. Himle; 20. Couples discord Matthew D. Johnson and Erin F. Alexander; 21. Psychotherapy relationships John C. Norcross and Christie P. Karpiak; Postscript. Evaluating treatments with the science-based Tolin criteria: a call-to-action Cassandra L. Boness, Stephen Hupp and David F. Tolin; Index.