John J. Rossi: RNA Therapeutics | Taschenbuch

Cover: 9780128215951 | RNA Therapeutics | The Evolving Landscape of RNA Therapeutics | Buch

Dekorationsartikel gehören nicht zum Leistungsumfang.

Sprache: Englisch

187,95 €*

inkl. MwSt.

Versandkostenfrei per Post / DHL

Lieferzeit 1-2 Wochen

Kategorien:

Der Artikel ist nicht in deutscher Sprache verfasst.
Die Sprache der Produktbeschreibung und Details kann in Englisch angegeben sein. Sollten Sie Verständnisprobleme haben, wenden Sie sich gerne an uns.

Beschreibung

Provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.

Inhaltsverzeichnis

SECTION 1 The world of RNA therapeutics: Available RNA tools to modulate cellular processes 1. Targeting chromatin: Transcriptional gene activation (saRNA) 2. Argonaute and TNRC6, partners in RNAi 3. Targeted RNA therapeutics for treatment of cancer and immunomodulation 4. Extrahepatic delivery of RNA to immune cells

SECTION 2 Learning from history 5. Aptamer-based protein inhibitors 6. Lessons learned from developing an oligonucleotide drug for a rare disease

SECTION 3 Delivery 7. Nucleoside modifications of in vitro transcribed mRNA to reduce immunogenicity and improve translation of prophylactic and therapeutic antigens 8. SOMAmer reagents and the SomaScan platform: Chemically modified aptamers and their applications in therapeutics, diagnostics, and proteomics

SECTION 4 From bench to bedside 9. CMC and regulatory aspects of oligonucleotide therapeutics 10. CMC: Regulatory landscape 11. CMC and manufacturing

SECTION 5 From bench to bedside 12. RNA delivery for cancer gene therapy 13. Combinatorial RNA therapies in cancer immunotherapy: Challenges and directions

Details

Erscheinungsjahr:	2022
Fachbereich:	Biophysik
Genre:	Biologie
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	Kartoniert / Broschiert
ISBN-13:	9780128215951
ISBN-10:	012821595X
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Rossi, John J. Giangrande, Paloma H. de Franciscis, Vittorio
Hersteller:	Elsevier Science Publishing Co Inc
Maße:	188 x 480 x 32 mm
Von/Mit:	John J. Rossi (u. a.)
Erscheinungsdatum:	13.04.2022
Gewicht:	0,984 kg

Artikel-ID: 119380244

Inhaltsverzeichnis

SECTION 2 Learning from history 5. Aptamer-based protein inhibitors 6. Lessons learned from developing an oligonucleotide drug for a rare disease

SECTION 4 From bench to bedside 9. CMC and regulatory aspects of oligonucleotide therapeutics 10. CMC: Regulatory landscape 11. CMC and manufacturing

SECTION 5 From bench to bedside 12. RNA delivery for cancer gene therapy 13. Combinatorial RNA therapies in cancer immunotherapy: Challenges and directions

Details

Erscheinungsjahr:	2022
Fachbereich:	Biophysik
Genre:	Biologie
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	Kartoniert / Broschiert
ISBN-13:	9780128215951
ISBN-10:	012821595X
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Rossi, John J. Giangrande, Paloma H. de Franciscis, Vittorio
Hersteller:	Elsevier Science Publishing Co Inc
Maße:	188 x 480 x 32 mm
Von/Mit:	John J. Rossi (u. a.)
Erscheinungsdatum:	13.04.2022
Gewicht:	0,984 kg